trans-2-hydroxycyclohexyl acetate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-2-hydroxycyclohexyl acetate
• 英文别名: 2-Acetoxycyclohexanol；(2-hydroxycyclohexyl) acetate
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: GCPZLJNKHNJVGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trans-2-hydroxycyclohexyl acetate 在 2,2,6,6-四甲基哌啶氧化物 、 四丁基溴化铵 作用下， 以 甲苯 为溶剂， 反应 15.0h， 生成 2-acetoxycyclohexanone
  参考文献：
  名称：

  一种多溶剂体系，可对内1,2-烷烃二元醇进行一锅式不对称化/氧化

  摘要：

  两个优于一个：我们证明的有机催化反应序列的沿着承载两个独立的催化功能，其允许快速，一锅acylative desymmetrization和氧化的短肽骨架的生存能力内消旋-烷烃-1,2-二醇来具有良好产率和对映选择性的相应乙酰化乙酰丙酮（参见方案）。

  DOI：

  10.1002/chem.201100498
• 作为产物：
  描述：

  环己烯 生成 trans-2-hydroxycyclohexyl acetate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Cobalt-Catalyzed Oxidations in Volumetrically Expanded Liquids by Compressed Gases
  申请人：Givens Richard S.

  公开号：US20080139841A1

  公开（公告）日：2008-06-12

  Oxidations of hydrocarbons, cycloalkanes and alkenes, arylalkanes, and a variety of other organic substrates are accomplished by cobalt-N-hydroxysuccinimide co-catalyzed reactions with dioxygen under unusually mild, near ambient conditions of temperature and pressure. The improved safety of the oxidation method and the high yields of product obtained make use of a unique combination of cobalt (II) complexes with N-hydroxysuccinimide. These autoxidation reactions do not have prolonged initiation times. Many of these reactions can be safely performed under normal chemical laboratory conditions and do not require specialized equipment or reagents.

  烃类、环烷烃、烯烃、芳基烷烃以及其他多种有机底物的氧化反应可以通过钴-N-羟基琥珀酰亚胺共催化反应与二氧化碳在异常温和、接近环境条件下的温度和压力下完成。氧化方法的改进安全性和获得的高产率产品利用了钴(II)络合物与N-羟基琥珀酰亚胺的独特组合。这些自氧化反应没有长时间的启动时间。许多这些反应可以在正常化学实验室条件下安全进行，不需要专门的设备或试剂。
• Aniline-terephthalaldehyde resin <i>p</i>-toluenesulfonate (ATRT) as a highly efficient and reusable catalyst for alcoholysis, hydrolysis, and acetolysis of epoxides
  作者：Kiyoshi Tanemura、Tsuneo Suzuki

  DOI：10.1080/00397911.2016.1223309

  日期：2016.11.16

  ABSTRACT Alcoholysis, hydrolysis, and acetolysis of epoxides were carried out in the presence of a catalytic amount of aniline-terephthalaldehyde resin p-toluenesulfonate (ATRT) to give the corresponding β-substituted alcohols in good yields. Alcoholysis and hydrolysis of epoxides catalyzed by ATRT proceeded faster than those by pyridinium p-toluenesulfonate (PPTS). GRAPHICAL ABSTRACT

  摘要 在催化量的苯胺-对苯二醛树脂对甲苯磺酸酯 (ATRT) 存在下进行环氧化物的醇解、水解和乙酰化，以良好的收率得到相应的 β-取代醇。由 ATRT 催化的环氧化物的醇解和水解比对甲苯磺酸吡啶 (PPTS) 进行得更快。图形概要
• [EN] SYNTHETIC MOLECULES HAVING IMMUNE ACTIVITY<br/>[FR] MOLECULES SYNTHETIQUES A IMMUNO-ACTIVITE
  申请人：MALAGHAN INST OF MEDICAL RES

  公开号：WO2005049631A1

  公开（公告）日：2005-06-02

  The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosaccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.

  本发明涉及具有类似于PIM（酰基甘油磷脂肌醇寡糖）活性的合成分子，用于治疗和预防炎症性或免疫细胞介导的疾病或紊乱。
• Synthetic Molecules Having Immune Activity
  申请人：Singh-Gill Gurmit

  公开号：US20080249037A1

  公开（公告）日：2008-10-09

  The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosacccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.

  本发明涉及具有类似于PIM（酰基甘油磷酰肌醇低聚糖）活性的合成分子，用于治疗和预防由炎症或免疫细胞介导的疾病或障碍。
• Lipophilic Oligopeptides for Chemo- and Enantioselective Acyl Transfer Reactions onto Alcohols
  作者：Christian E. Müller、Daniela Zell、Radim Hrdina、Raffael C. Wende、Lukas Wanka、Sören M. M. Schuler、Peter R. Schreiner

  DOI：10.1021/jo401195c

  日期：2013.9.6

  Inspired by the extraordinary selectivities of acylases, we envisioned the use of lipophilic oligopeptidic organocatalysts for the acylative kinetic resolution/desymmetrization of rac- and meso-cycloalkane-1,2-diols. Here we describe in a full account the discovery and development process from the theoretical concept to the final catalyst, including scope and limitations. Competition experiments with various alcohols and electrophiles show the full potential of the employed oligopeptides. Additionally, we utilized NMR and IR-spectroscopic methods as well as computations to shed light on the factors responsible for the selectivity. The catalyst system can be readily modified to a multicatalyst by adding other catalytically active amino acids to the peptide backbone, enabling the stereoselective one-pot synthesis of complex molecules from simple starting materials.