2-Hydroxymethyl-6-mercapto-tetrahydro-pyran-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxymethyl-6-mercapto-tetrahydro-pyran-3,4,5-triol
• 英文别名: 2-(hydroxymethyl)-6-sulfanyloxane-3,4,5-triol
• 化学式: C₆H₁₂O₅S
• 分子量: 196.224
• InChiKey: JUSMHIGDXPKSID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  91.2
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Reagents And Methods For The Formation Of Disulfide Bonds And The Glycosylation Of Proteins
  申请人：Davis Guy Benjamin

  公开号：US20070213506A1

  公开（公告）日：2007-09-13

  Methods and reagents for the formation of disulfide bonds, particularly in proteins, peptides and amino acids. The methods and reagents are particularly useful for the controlled glycosylation of proteins, peptides and amino acids. The methods utilise thiosulfonate or selenenylsulfide compounds as reagents or intermediates. Some proteins and peptides comprising selenenyl-sulfide groups also form part of the invention.

  本发明涉及在蛋白质、肽和氨基酸中形成二硫键的方法和试剂，特别是用于蛋白质、肽和氨基酸的可控糖基化。所述方法利用硫代磺酸盐或硒酰硫酸盐化合物作为试剂或中间体。一些含有硒酰硫酸盐基团的蛋白质和肽也是本发明的一部分。
• WATER SOLUBLE NEAR INFRARED SENSING POLYMERS WITH LOW BAND GAPS
  申请人：Xue Cuihua

  公开号：US20120322944A1

  公开（公告）日：2012-12-20

  The present invention is directed to polymeric materials including a copolymer of at least a first and second monomer that have desirable electrical and optical properties, such as a low band gap and near infrared (NIR) absorption, respectively. More specifically, the present invention is directed to polymeric materials with charge neutrality that display increased solubility in aqueous media while retaining their electrical and optical properties. The polymeric materials in accordance with the present invention can be modified with any desired functional group to tailor the polymer materials for a specific application. Also described are methods of making the polymeric materials in accordance with the present invention.

  本发明涉及聚合物材料，包括至少第一和第二单体的共聚物，具有理想的电学和光学性能，例如低带隙和近红外吸收。更具体地说，本发明涉及具有电荷中性的聚合物材料，其在水介质中显示出增加的溶解度，同时保持其电学和光学性能。根据本发明的聚合物材料可以通过任何所需的功能基团进行改性，以为特定应用定制聚合物材料。还描述了根据本发明制备聚合物材料的方法。
• Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
  申请人：Novartis AG

  公开号：US10081697B2

  公开（公告）日：2018-09-25

  The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

  本发明提供了一种亲水聚二有机硅氧烷乙烯基交联剂，它包括(1)聚二有机硅氧烷聚合物链，该链由二甲基硅氧烷单元和亲水硅氧烷单元组成，每个二甲基硅氧烷单元具有一个甲基取代基和一个具有二至六个羟基的单价C4-C40有机基取代基，其中亲水硅氧烷单元与二甲基硅氧烷单元的摩尔比为约0.035至约0.15，以及(2)两个末端(甲基)丙烯酰基。亲水性聚二有机硅氧烷乙烯基交联剂的平均分子量为约 3000 道尔顿至约 80000 道尔顿。本发明还涉及一种硅酮水凝胶隐形眼镜，它包括由本发明的亲水聚二有机硅氧烷乙烯基交联剂衍生的重复单元。
• Silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US10875967B2

  公开（公告）日：2020-12-29

  The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

  本发明一般涉及具有相对较高透氧率、相对较高平衡水含量和相对较低弹性模量的固有可湿性硅水凝胶隐形眼镜。本发明还涉及制作这种固有可湿性硅水凝胶隐形眼镜的方法。
• REAGENTS AND METHODS FOR THE FORMATION OF DISULFIDE BONDS AND THE GLYCOSYLATION OF PROTEINS
  申请人：ISIS INNOVATION LIMITED

  公开号：EP1644390B1

  公开（公告）日：2011-04-20