(2,3,5,6-Tetrahydroxy-4-phosphonooxycyclohexyl) dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,3,5,6-Tetrahydroxy-4-phosphonooxycyclohexyl) dihydrogen phosphate
• 化学式: C₆H₁₄O₁₂P₂
• 分子量: 340.12
• InChiKey: PELZSPZCXGTUMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  214
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Process for the preparation of oxidized phospholipids
  申请人：Halperin Gideon

  公开号：US20070112211A1

  公开（公告）日：2007-05-17

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  本发明揭示了一种新的合成路线，非常适用于工业制备具有治疗益处的氧化磷脂类化合物。特别是，本发明揭示了一种高效制备具有甘油骨架和一个或多个氧化基团连接到甘油骨架上的化合物的新方法，该方法不需要使用柱层析。此外，本发明还揭示了将含磷基团（如磷酸盐基团）引入具有甘油骨架和由此形成的中间体的化合物的新方法。
• Oxidized lipids and uses thereof in the treatment of inflammatory diseases and disorders
  申请人：Harats Dror

  公开号：US20070099868A1

  公开（公告）日：2007-05-03

  Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

  本发明提供了一种新型合成氧化脂质及利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。
• Oxidized Lipids and Uses Thereof in the Treatment of Inflammatory Diseases and Disorders
  申请人：Harats Dror

  公开号：US20080261865A1

  公开（公告）日：2008-10-23

  Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

  本发明提供了新型合成的氧化脂质以及利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。
• OXIDIZED LIPIDS AND USES THEREOF IN THE TREATMENT OF INFLAMMATORY DISEASES AND DISORDERS
  申请人：HARATS Dror

  公开号：US20110189212A1

  公开（公告）日：2011-08-04

  Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.

  本发明提供了一种新型合成氧化脂质以及利用氧化脂质治疗和预防与内源性氧化脂质相关的炎症的方法。
• PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS
  申请人：Halperin Gideon

  公开号：US20120130108A1

  公开（公告）日：2012-05-24

  Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

  本发明揭示了一种新型合成路线，适用于工业制备治疗有益的氧化磷脂。特别是，揭示了一种高效制备具有甘油骨架和一个或多个氧化物附着在甘油骨架上的化合物的新方法，这些方法不需要柱层析。此外，还揭示了一种引入含磷基团（如磷酸盐基团）到具有甘油骨架的化合物和由此形成的中间体的新方法。