9-(3,4,5-trihydroxyoxan-2-yl)-3H-purin-6-one | 18520-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-(3,4,5-trihydroxyoxan-2-yl)-3H-purin-6-one
• 英文别名: 9-(3,4,5-trihydroxyoxan-2-yl)-1H-purin-6-one
• CAS: 18520-78-0；18520-88-2
• 化学式: C₁₀H₁₂N₄O₅
• 分子量: 268.23
• InChiKey: UKUBRHKAZHFGHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• PROCESS FOR PREPARING (-)PYRIDOBENZOXAZINE CARBOXYLIC ACID DERIVATIVES
  申请人：SAMSUNG ELECTRONICS CO., LTD.

  公开号：EP1073662A1

  公开（公告）日：2001-02-07
• EP1073662A4
  申请人：——

  公开号：EP1073662A4

  公开（公告）日：2002-04-17
• US6316618B1
  申请人：——

  公开号：US6316618B1

  公开（公告）日：2001-11-13
• [EN] PROCESS FOR PREPARING (-)PYRIDOBENZOXAZINE CARBOXYLIC ACID DERIVATIVES<br/>[FR] PROCEDE DE PREPARATION DE DERIVES DE L'ACIDE (-)PYRIDOBENZOXAZINE CARBOXYLIQUE
  申请人：SAMSUNG ELECTRONICS CO LTD

  公开号：WO2000050428A1

  公开（公告）日：2000-08-31

  The present invention provides a process for preparing optically active (-)pyridobenzoxazine carboxylic acid derivative and pharmaceutically acceptable salt thereof by employing a starting material of (+)ethyl 2-(4-chloro-5-fluoro-2-halo-3-nitobenzoyl)-3-[(1-hydroxypropy-2(S)-yl)amino]acrylate. According to the present invention, optically active (-)pyridobenzoxazine carboxylic acid derivative can be manufactured from low-priced 4-chloro-5-fluorobenzoic acid derivative in a simple and economical manner.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FAT METABOLISM<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES PERMETTANT DE MODULER LE METABOLISME DES GRAISSES
  申请人：OBETHERAPY BIOTECHNOLOGY

  公开号：WO2004037159A2

  公开（公告）日：2004-05-06

  Methods, compositions and methods of identifying candidate compounds, for modulating fat metabolism and/or inhibiting Apobec-1 activity are provided.