4-(Hydroxymethyl)cyclohexane-1,2,3-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(Hydroxymethyl)cyclohexane-1,2,3-triol
• 化学式: C₇H₁₄O₄
• 分子量: 162.18
• InChiKey: HSWSNXXNDSZDNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Methods of treating Fabry patients having renal impairment
  申请人：Amicus Therapeutics, Inc.

  公开号：US11376244B2

  公开（公告）日：2022-07-05

  Provided are methods for treatment of Fabry disease in patients having HEK assay amenable mutations in α-galactosidase A. Certain methods comprise administering migalastat or a salt thereof every other day, such as administering about 150 mg of migalastat hydrochloride every other day.

  某些方法包括每隔一天给药一次米格司他或其盐，例如每隔一天给药约150毫克盐酸米格司他。
• [EN] COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE CONTRÔLE MODULAIRE D'UNE LIGATURE BIO-ORTHOGONALE
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2020113077A9

  公开（公告）日：2020-08-13
• INHIBITION OF ENDOSOMAL TOLL-LIKE RECEPTOR ACTIVATION
  申请人：DUKE UNIVERSITY

  公开号：US20170095503A1

  公开（公告）日：2017-04-06

  The present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced activation of, for example, endosomal TLRs using an agent that binds to the nucleic acid (“nucleic acid binding agent”), preferably, in a manner that is independent of the nucleotide sequence, the chemistry (e.g., DNA or RNA, with or without base or sugar modifications) and/or the structure (e.g., double-stranded or single-stranded, complexed or uncomplexed with, for example protein) of the nucleic acid(s) responsible for inducing TLR activation. The invention also relates to methods of identifying nucleic acid binding agents suitable for use in such methods.
• COMPOSITIONS AND METHODS FOR MODULAR CONTROL OF BIOORTHOGONAL LIGATION
  申请人：LAUGHLIN Scott

  公开号：US20220218661A1

  公开（公告）日：2022-07-14

  The present invention provides a compound having the structure: wherein R 1 is H or a protecting group; R 2 and R 3 are each independently H, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl-C(O)NHR 6 , C 1 -C 6 alkyl-C(O)OR 6 , wherein R 6 is H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, or R 2 and R 3 combine to form a 3-7 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and R 4 and R 5 are each independently halo.
• US9708263B2
  申请人：——

  公开号：US9708263B2

  公开（公告）日：2017-07-18