gamm-glutamylglycine | 1948-29-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: gamm-glutamylglycine
• 英文别名: gamma-glutamylglycine；γ-Glutamyl-glycin；N-DL-γ-glutamyl-glycine；DL-2-Amino-glutarsaeure-5-carboxymethylamid；N-DL-γ-Glutamyl-glycin；γ-D-glutamylglycine；2-amino-5-(carboxymethylamino)-5-oxopentanoic acid
• CAS: 1948-29-4
• 化学式: C₇H₁₂N₂O₅
• 分子量: 204.183
• InChiKey: ACIJGUBIMXQCMF-UHFFFAOYSA-N

物化性质

• 熔点：
  193-194 °C
• 沸点：
  586.6±50.0 °C(Predicted)
• 密度：
  1.424±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 海关编码：
  2924199090

制备方法与用途

γ-Glu-Gly 是一种 γ-谷氨酰二肽，它是人体脂质代谢的产物。它与 GABA（γ-氨基丁酸）具有相似的结构，并能作为一种兴奋性氨基酸的拮抗剂。

反应信息

• 作为反应物：
  描述：

  gamm-glutamylglycine 在 水 、 magnesium oxide 、 氯甲酸苄酯 作用下， 生成 N-(N-benzyloxycarbonyl-DL-γ-glutamyl)-glycine
  参考文献：
  名称：

  Processing of highly oriented lithium tantalate films by chemical solution deposition

  摘要：

  研究了用化学溶液沉积法合成钽酸锂薄膜的方法。前驱体溶液由乙醇溶解乙醇锂和五氧化二钽制备而成。在该前驱体溶液中加入甲酸能非常有效地通过旋涂法在基底上制备出均匀透明的前驱体薄膜。钽酸锂薄膜在蓝宝石（001）基底上结晶，在 450 °C 以上的温度下进行热处理时，沿 c 轴的取向非常优选。550 °C 时制备的薄膜折射率为 2.049，接近钽酸锂单晶体的折射率（2.176）。

  DOI：

  10.1557/jmr.2002.0368
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 、 一水合肼 作用下， 生成 gamm-glutamylglycine
  参考文献：
  名称：

  693.由邻苯二甲酰化中间体合成谷氨酰胺和谷氨酸γ-二肽的新方法

  摘要：

  DOI：

  10.1039/jr9490003315

文献信息

• LABELED MOLECULAR IMAGING AGENTS AND METHODS OF USE
  申请人：Webster Jack Mathew

  公开号：US20130071332A1

  公开（公告）日：2013-03-21

  Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

  描述了包含标记底物的成像剂，这些底物能够通过半胱氨酸/谷氨酸逆运输体引入细胞中。这些底物可以通过将标记剂通过半胱氨酸/谷氨酸逆运输体引入细胞中并进行后续检测，用于成像或检测细胞中的氧化应激。
• TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY
  申请人：Jung Francoise

  公开号：US20120283168A1

  公开（公告）日：2012-11-08

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  具有以下一般式(I)的小说模板固定β-发夹仿生肽，其中单个元素T或P是α-氨基酸残基，可以连接在任何方向上，具体取决于它们在链中的位置，如描述和索赔中所定义，及其盐，具有拮抗受体CCR10的特性。它们可用作药物，用于治疗或预防皮肤病和皮肤疾病、炎症、过敏性疾病、呼吸道疾病、胃肠道疾病、眼科疾病、血液学和癌症等领域。这些β-发夹仿生肽可以通过基于混合固相和溶液相合成策略的过程制备。
• Reagents for assay of gamma-glutamyl-transpeptidase
  申请人：UNITIKA LTD.

  公开号：EP0266905A1

  公开（公告）日：1988-05-11

  A reagent for assaying γ-glutamyltranspeptidase (γ-GTP) which contains an amino acid dehydrogenase and a substrate specific to γ-glutamyltranspeptidase activity. The reagent can be used to assay the γ-GTP activity directly from the continuous course of reaction without using a standard substance with known activity. The procedure required is simple and easy, and the reagent is capable of determining γ-GTP activity with good accuracy and without affecting by interfering substances, making it satisfactory for routine use in clinical laboratories.

  一种用于测定γ-谷氨酰转肽酶（γ-GTP）的试剂，它含有氨基酸脱氢酶和对γ-谷氨酰转肽酶活性有特异性的底物。该试剂无需使用已知活性的标准物质，即可直接从连续反应过程中检测 γ-GTP 活性。该试剂所需的步骤简单易行，能够准确测定 γ-GTP 活性，且不受干扰物质的影响，因此非常适合临床实验室的常规使用。
• MUTANT GLUTAMATE-CYSTEINE LIGASE AND METHOD FOR MANUFACTURING GAMMA-GLUTAMYL-VALYL-GLYCINE
  申请人：Ajinomoto Co., Inc.

  公开号：EP3101130A1

  公开（公告）日：2016-12-07

  A mutant glutamate-cysteine ligase (GSHA) suitable for generating γ-Glu-Val, and a method for producing γ-Glu-Val-Gly using the same are provided. γ-Glu-Val is produced by using a mutant GSHA having a specific mutation with Glu and Val as raw materials, and γ-Glu-Val-Gly is further produced by using γ-Glu-Val and Gly as raw materials. γ-Glu-Val-Gly is produced by using a mutant GSHA having a specific mutation with Glu, Val, and Gly as raw materials.

  本研究提供了一种适用于生成γ-Glu-Val的突变体谷氨酸-半胱氨酸连接酶（GSHA），以及使用该突变体生成γ-Glu-Val-Gly的方法。γ-Glu-Val是以具有特定突变的GSHA为原料，以Glu和Val为突变体生产出来的，而γ-Glu-Val-Gly则是以γ-Glu-Val和Gly为原料进一步生产出来的。γ-Glu-Val-Gly 是以具有特定突变的 GSHA 为原料，以 Glu、Val 和 Gly 为突变体生产出来的。
• METHOD FOR PRODUCING -GLUTAMYL-VALYL-GLYCINE
  申请人：Ajinomoto Co., Inc.

  公开号：EP3345996A1

  公开（公告）日：2018-07-11

  A microorganism useful as an expression host for γ-Glu-Val synthetase and a method for producing γ-Glu-Val-Gly using γ-Glu-Val synthetase expressed in the microorganism are provided. By using γ-Glu-Val synthetase expressed in a bacterium, such as Escherichia bacteria, modified so that the activity of a protein encoded by a ybdK gene (YBDK) is reduced as an expression host, γ-Glu-Val-Gly is produced from Glu, Val, and Gly as raw materials.

  本发明提供了一种可作为γ-谷氨酰缬氨酸合成酶表达宿主的微生物，以及一种利用在该微生物中表达的γ-谷氨酰缬氨酸合成酶生产γ-谷氨酰缬氨酸的方法。通过使用在细菌（如埃希氏细菌）中表达的γ-Glu-Val 合成酶作为表达宿主，该细菌经过改良，降低了由 yBDK 基因（YBDK）编码的蛋白质的活性，从而以 Glu、Val 和 Gly 为原料生产出γ-Glu-Val-Gly。