8-(3-Hept-6-enyloxiran-2-yl)octa-4,6-diyn-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-(3-Hept-6-enyloxiran-2-yl)octa-4,6-diyn-3-one
• 英文别名: 8-(3-hept-6-enyloxiran-2-yl)octa-4,6-diyn-3-one
• 化学式: C₁₇H₂₂O₂
• 分子量: 258.35
• InChiKey: APJAEUNKQUJNFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  29.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS
  申请人：Hans, Joachim

  公开号：EP2812005A1

  公开（公告）日：2014-12-17
• [EN] POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS<br/>[FR] ACIDES TRITERPÈNES PENTACYLIQUES POLYHYDROXYLÉS EN TANT QU'INHIBITEURS D'HMG-COA RÉDUCTASE
  申请人：HANS JOACHIM

  公开号：WO2013171100A1

  公开（公告）日：2013-11-21

  The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-Co A reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-Co A reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.