(-)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin | 93158-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin
• 英文别名: <2-Hydroxy-2,5,5,8a-tetramethyl-decahydro-naphthyl-(1)>-essigsaeure；(2-Hydroxy-2,5,5,8a-tetramethyl-decahydro-naphthyl-(1))-essigsaeure；(2-Hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)acetic acid；2-(2-hydroxy-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl)acetic acid
• CAS: 93158-29-3
• 化学式: C₁₆H₂₈O₃
• 分子量: 268.397
• InChiKey: ASWLRRLLSBVSOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] A PROCESS FOR THE OPTICAL RESOLUTION OF A PRECURSOR OF SCLAREOLIDE<br/>[FR] PROCEDE DE RESOLUTION OPTIQUE D'UN PRECURSEUR DU SCLAREOLIDE
  申请人：FIRMENICH & CIE

  公开号：WO2004013069A1

  公开（公告）日：2004-02-12

  The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. Said process is characterized by the reaction of [(1RS,2RS,4aSR,8aSR)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]acetic acid, or an alkaline salt thereof, with an enantiomer of the 2-(methylamino)-1-phenyl-1-propanol, or an ammonium salt thereof respectively, which is used as resolving agent.

  本发明涉及有机合成领域，更具体地涉及一种用于光学分辨前驱物斯氯酮酸的新工艺。该工艺的特点是将[(1RS,2RS,4aSR,8aSR)-2-羟基-2,5,5,8a-四甲基癸氢萘-1-基]乙酸或其碱盐与2-(甲胺基)-1-苯基-1-丙醇的对映体或其铵盐分别反应，后者用作分离剂。
• Process for the optical resolution of a precursor of sclareolide
  申请人：——

  公开号：US20040192960A1

  公开（公告）日：2004-09-30

  The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. This process includes the reaction of [(1RS,2RS,4aSR,8aSR)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl]acetic acid, or an alkaline salt thereof, with an enantiomer of the 2-(methylamino)-1-phenyl-1-propanol, or an ammonium salt thereof respectively, which is used as resolving agent.

  本发明涉及有机合成领域，更具体地说，它涉及一种新工艺，用于斯卡雷内酯前体的光学解析。该工艺包括[(1RS,2RS,4aSR,8aSR)-2-羟基-2,5,5,8a-四甲基十氢萘-1-基]乙酸或其碱性盐分别与 2-(甲基氨基)-1-苯基-1-丙醇的对映体或其铵盐反应，后者用作解析剂。
• Novel hydroxylated enantiomers of (-) 3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan as perfuming agents derived from a fungal fermentation process.
  申请人：Rahman Attaur

  公开号：US20060223883A1

  公开（公告）日：2006-10-05

  (−) 3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan (ambrox) is a strong aromatic compound used widely in a variety of perfumery applications and is highly prized for its musky odor. We report novel polar metabolites of (−)3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan prepared by a novel process of microbial fermentation using a fungi, Fusarium lini , of unique structures that would be difficult to predict opening up the possibilities of their chemical synthesis. The polar metabolites discovered have stronger aromatic characteristics and offer a new highly prized odiferous characteristic quite different from that of the parent compound and thus can be used in the preparation of perfumes, odor-masking and other odor-management applications.

  (-)3a,6,6,9a-四甲基全氢萘并[2,1-b]呋喃（ambrox）是一种强烈的芳香化合物，广泛应用于各种香水中，因其麝香气味而备受青睐。我们报告了一种新型的 (-)3a,6,6,9a-四甲基全氢萘并[2,1-b]呋喃的极性代谢物，这种代谢物是通过使用真菌 Fusarium lini 进行微生物发酵而制备的，其结构独特，难以预测，为化学合成提供了可能性。所发现的极性代谢物具有更强的芳香特性，并提供了与母体化合物截然不同的新的珍贵气味特性，因此可用于制备香水、掩盖气味和其他气味管理应用。
• Process for producing L-Ambrox
  申请人：KURARAY Co. LTD.

  公开号：EP0550889B1

  公开（公告）日：1996-09-18
• A PROCESS FOR THE OPTICAL RESOLUTION OF A PRECURSOR OF SCLAREOLIDE
  申请人：FIRMENICH SA

  公开号：EP1527034A1

  公开（公告）日：2005-05-04