4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)-morpholine | 879205-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)-morpholine
• 英文别名: 4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)morpholine；(3R)-N-[4-[(2S)-4-[(1R)-1-phenylethyl]morpholin-2-yl]phenyl]oxolan-3-amine
• CAS: 879205-88-6
• 化学式: C₂₂H₂₈N₂O₂
• 分子量: 352.477
• InChiKey: YWYTYLTWJBUACV-ZPMCFJSWSA-N

物化性质

• 沸点：
  503.6±50.0 °C(Predicted)
• 密度：
  1.161±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)-morpholine 在 palladium 10% on activated carbon 甲酸铵 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 1.0h， 以100%的产率得到(2S)-2-[4-{N-((3R)-tetrahydrofuran-3-yl)amino}phenyl]morpholine
  参考文献：
  名称：

  [EN] 6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS
  [FR] COMPOSE PYRIMIDONE

  摘要：

  公开号：

  WO2006036015A3
• 作为产物：
  描述：

  (2S)-2-(4-bromophenyl)-4-[(1R)-1-phenylethyl]morpholine 、 (R)-(+)-3-aminotetrahydrofuran toluene-4-sulfonate 在 palladium diacetate 、 2-(二叔丁基膦)联苯 sodium t-butanolate 作用下， 以 叔丁醇 为溶剂， 反应 6.0h， 以53%的产率得到4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)-morpholine
  参考文献：
  名称：

  [EN] 6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS
  [FR] COMPOSE PYRIMIDONE

  摘要：

  公开号：

  WO2006036015A3

文献信息

• [EN] 2-MORPHOLINO-4-PYRIMIDONE COMPOUND<br/>[FR] COMPOSE 2-MORPHOLINO-4-PYRIMIDONE
  申请人：MITSUBISHI PHARMA CORP

  公开号：WO2006028290A1

  公开（公告）日：2006-03-16

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; 1 represents a C1-C12 alkyl; R2 represents a hydrogen atom, or the like; R' represents a C1-C6 alkyl or the like; q represents 0 or an integer of 1 to 7; Y represents a C1-C6 alkyl or the like; p represents 0 or an integer of 1 to 5; R represents a 2,3-dihydroindolyl or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式（I）所代表的化合物，其光学活性异构体，或其药用可接受盐：其中X代表CH或N；1代表C1-C12烷基；R2代表氢原子，或类似物；R'代表C1-C6烷基或类似物；q代表0或1至7的整数；Y代表C1-C6烷基或类似物；p代表0或1至5的整数；R代表2,3-二氢吲哚基或类似物，用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，如神经退行性疾病（例如阿尔茨海默病）。
• 2-MORPHOLINO-4-PYRIMIDONE COMPOUND
  申请人：WATANABE Kazutoshi

  公开号：US20090124618A1

  公开（公告）日：2009-05-14

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom, or the like; R′ represents a C 1 -C 6 alkyl or the like; q represents 0 or an integer of 1 to 7; Y represents a C 1 -C 6 alkyl or the like; p represents 0 or an integer of 1 to 5; R represents a 2,3-dihydroindolyl or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I），其手性异构体或药物可接受的盐：其中X代表CH或N；代表C1-C12烷基；R2代表氢原子或类似物；R'代表C1-C6烷基或类似物；q代表0或1至7的整数；Y代表C1-C6烷基或类似物；p代表0或1至5的整数；R代表2,3-二氢吲哚基或类似物，用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，例如神经退行性疾病（例如阿尔茨海默病）。
• 6- (PYRIDINYL) -4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS
  申请人：Watanabe Kazutoshi

  公开号：US20090239864A1

  公开（公告）日：2009-09-24

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R 1 represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom or the like; R 3 represents a halogen or the like; q represents an integer of 1 to 7; R 4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R 5 represents a C 6 -C 10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I），其手性异构体，或其药学可接受的盐：其中R1表示C1-C12烷基；R2表示氢原子或类似物；R3表示卤素或类似物；q表示1至7的整数；R4表示卤素或类似物；p表示0或1至5的整数；R5表示C6-C10芳基，杂环或类似物；X表示氧，NH或类似物，用于预防和/或治疗由tau蛋白激酶1高活性引起的疾病，例如神经退行性疾病（如阿尔茨海默病）。
• 2-morpholino-4-pyrimidone compound
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：US08106045B2

  公开（公告）日：2012-01-31

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein X represents CH or N; represents a C1-C12 alkyl; R2 represents a hydrogen atom, or the like; R′ represents a C1-C6 alkyl or the like; q represents 0 or an integer of 1 to 7; Y represents a C1-C6 alkyl or the like; p represents 0 or an integer of 1 to 5; R represents a 2,3-dihydroindolyl or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I），其对映异构体或药学上可接受的盐：其中X代表CH或N；代表C1-C12烷基；R2代表氢原子或类似物；R'代表C1-C6烷基或类似物；q代表0或1到7的整数；Y代表C1-C6烷基或类似物；p代表0或1到5的整数；R代表2,3-二氢吲哚基或类似物，用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，例如神经退行性疾病（例如阿尔茨海默病）。
• 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：US08129377B2

  公开（公告）日：2012-03-06

  A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R1 represents a C1-C12 alkyl; R2 represents a hydrogen atom or the like; R3 represents a halogen or the like; q represents an integer of 1 to 7; R4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R5 represents a C6-C10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

  化合物的化学式为（I），其手性异构体或药物可接受的盐：其中，R1代表C1-C12烷基；R2代表氢原子或类似物；R3代表卤素或类似物；q代表1至7的整数；R4代表卤素或类似物；p代表0或1至5的整数；R5代表C6-C10芳基，杂环或类似物；X代表氧、NH或类似物，用于预防和/或治疗由tau蛋白激酶1过度活化引起的疾病，如神经退行性疾病（例如阿尔茨海默病）。