5-Guanidino-2-hydroxypentanoic acid | 462-64-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Guanidino-2-hydroxypentanoic acid
• 英文别名: 5-(diaminomethylideneamino)-2-hydroxypentanoic acid
• CAS: 462-64-6
• 化学式: C₆H₁₃N₃O₃
• 分子量: 175.19
• InChiKey: BMFMQGXDDJALKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Methods for treating of skin conditions with retinoid double conjugate compounds
  申请人：US COSMECEUTECHS LLC

  公开号：US10123960B2

  公开（公告）日：2018-11-13

  A double conjugate molecule made of a retinoid, an organic acid, particularly an a-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.

  提供一种由视黄醇、有机酸（特别是α-羟基酸）和醇或酰基组成的双共轭分子，可用于治疗皮肤状况，特别是衰老。视黄醇、有机酸和醇/酰基组最好通过酯键连接。
• PROCESS FOR THE DIRECT AMINATION OF SECONDARY ALCOHOLS WITH AMMONIA TO GIVE PRIMARY AMINES
  申请人：Klasovsky Florian

  公开号：US20130165672A1

  公开（公告）日：2013-06-27

  The invention relates to a process for preparing primary amines which comprises the process steps A) provision of a solution of a secondary alcohol in a fluid, nongaseous phase, B) contacting of the phase with free ammonia and/or at least one ammonia-releasing compound and a homogeneous catalyst and optionally C) isolation of the primary amine formed in process step B), characterized in that the volume ratio of the volume of the liquid phase to the volume of the gas phase in process step B is greater than or equal to 0.25, and/or in that the ammonia is used in process step B) in a molar ratio based on the hydroxyl groups in the secondary alcohol of at least 5:1.

  该发明涉及一种制备初级胺的方法，包括以下步骤：A）提供在流体非气态相中的二级醇溶液，B）将该相与游离氨和/或至少一种释放氨的化合物以及均相催化剂接触，并可选C）分离在步骤B中形成的初级胺，其特征在于，步骤B中液相体积与气相体积的体积比大于或等于0.25，和/或在步骤B中使用的氨以基于二级醇中羟基的摩尔比至少为5:1。
• RETINOID DOUBLE CONJUGATE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS FOR TREATING OF SKIN CONDITIONS
  申请人：US CosmeceuTechs LLC

  公开号：EP3068495A1

  公开（公告）日：2016-09-21
• US4363815A
  申请人：——

  公开号：US4363815A

  公开（公告）日：1982-12-14
• US8927773B2
  申请人：——

  公开号：US8927773B2

  公开（公告）日：2015-01-06