1-[12-(1-Difluoromethyl-cyclopropyl)-dodecyl]-cyclopropanecarboxylic acid | 1365572-10-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-[12-(1-Difluoromethyl-cyclopropyl)-dodecyl]-cyclopropanecarboxylic acid
• 英文别名: 1-[12-[1-(difluoromethyl)cyclopropyl]dodecyl]cyclopropane-1-carboxylic acid
• CAS: 1365572-10-6
• 化学式: C₂₀H₃₄F₂O₂
• 分子量: 344.486
• InChiKey: IHUFDSHTNNMNMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,15-dicyclopropyl-hexadecanedioic acid 在 氯化亚砜 、 草酰氯 、 二乙胺基三氟化硫 、 dimethyl sulfide borane 、 水 、 二甲基亚砜 、 potassium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 66.08h， 生成 1-[12-(1-Difluoromethyl-cyclopropyl)-dodecyl]-cyclopropanecarboxylic acid
  参考文献：
  名称：

  METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA

  摘要：

  该发明涉及一种新型化合物的公式I：以及其立体异构体和/或药用盐，用于治疗糖尿病和与糖尿病相关的血脂异常。

  公开号：

  US20120071528A1

文献信息

• Methods and compositions for treatment of diabetes and dyslipidemia
  申请人：Khanna Ish

  公开号：US08623897B2

  公开（公告）日：2014-01-07

  The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.

  本发明涉及一种新的化合物I，以及它的立体异构体和/或药学上可接受的盐，用于治疗糖尿病和与糖尿病相关的血脂异常。
• US8623897B2
  申请人：——

  公开号：US8623897B2

  公开（公告）日：2014-01-07
• [EN] METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DU DIABÈTE ET DE LA DYSLIPIDÉMIE
  申请人：KAREUS THERAPEUTICS SA

  公开号：WO2012040177A1

  公开（公告）日：2012-03-29

  Novel compounds of Formula I are provided: its stereoisomers and/or pharmaceutically acceptable salts for the treatment of diabetes and diabetes-associated dyslipidemia, wherein R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO2R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR' wherein R' is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy; and n1 and n2 are independently selected from 0, 1, and 2. At least one of R3 and R4 and/or R5 and R6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO2. Additionally, when R3 and R4 or R5 and R6 do not form a cyclic ring, then they may be independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl. L1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms. The chain may optionally be substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl. R2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR7, wherein R7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR', NHSO2R, or NHCOR. Y1 is oxygen or hydrogen. Y2 is optional, wherein when Y2 is present, Y1 and Y2 are hydrogen. When Y2 is not present, Y1 is a carbonyl group.
• METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA
  申请人：Khanna Ish

  公开号：US20120071528A1

  公开（公告）日：2012-03-22

  The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.

  该发明涉及一种新型化合物的公式I：以及其立体异构体和/或药用盐，用于治疗糖尿病和与糖尿病相关的血脂异常。