3-phenyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 3-phenyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
• 化学式: C₁₅H₁₂N₂O₂
• mdl: MFCD13273360
• 分子量: 252.272
• InChiKey: CCYJSRLAYJMCGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  o-azidobenzoyl chloride 在 溶剂黄146 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成 3-phenyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione
  参考文献：
  名称：

  One pot conversion of azido arenes to N-arylacetamides and N-arylformamides: synthesis of 1,4-benzodiazepine-2,5-diones and fused [2,1-b]quinazolinones

  摘要：

  Sodium iodide in acidic media has been employed for the synthesis of N-arylformamides and N-arylacetamides. The NaI/acetic acid reagent system has also been extended for the synthesis of 1,4-benzodiazepine-2,5-diones, pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones, and fused [2,1-b]quinazolinones. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2004.09.046

文献信息

• Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase
  申请人：Leit Silvana

  公开号：US20070155730A1

  公开（公告）日：2007-07-05

  This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein A, B, D, E, X 1 , X 2 , X 3 , X 4 and n are as defined in the specification.

  本发明涉及用于抑制组蛋白去乙酰化酶的化合物。更具体地说，该发明提供了式（I）中A、B、D、E、X1、X2、X3、X4和n所定义的化合物。
• One pot conversion of azido arenes to N-arylacetamides and N-arylformamides: synthesis of 1,4-benzodiazepine-2,5-diones and fused [2,1-b]quinazolinones
  作者：Ahmed Kamal、A. Venkata Ramana、K. Srinivasa Reddy、K. Venkata Ramana、A. Hari Babu、B. Rajendra Prasad

  DOI：10.1016/j.tetlet.2004.09.046

  日期：2004.10

  Sodium iodide in acidic media has been employed for the synthesis of N-arylformamides and N-arylacetamides. The NaI/acetic acid reagent system has also been extended for the synthesis of 1,4-benzodiazepine-2,5-diones, pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones, and fused [2,1-b]quinazolinones. (C) 2004 Published by Elsevier Ltd.