5-Amino-3,5-dideoxynon-2-ulopyranosonic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Amino-3,5-dideoxynon-2-ulopyranosonic acid
• 英文别名: 5-amino-2,4-dihydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
• 化学式: C₉H₁₇NO₈
• 分子量: 267.23
• InChiKey: CERZMXAJYMMUDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  174
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• [EN] VIRUS DETECTION<br/>[FR] DÉTECTION DE VIRUS
  申请人：UNIV EAST ANGLIA

  公开号：WO2015011441A1

  公开（公告）日：2015-01-29

  The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticule, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus – for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

  该发明提供了一种用于检测流感病毒的方法和材料，该方法利用纳米颗粒，例如金纳米颗粒探针，包括多种糖蛋白配体的多糖脂蛋白配体，每个糖脂蛋白配体（GL）具有多个含唾液酸的识别基团（Y），通过多价核心（X）与纳米颗粒结合，其中多价核心（X）是三价核心，因此每个配体有3个识别基团，生物共轭物上的识别基团特异性地结合到目标流感病毒的血凝素上。探针还可以包括与纳米颗粒结合的其他不特异结合到流感病毒的配体，例如聚乙二醇基团。这些可以调节纳米颗粒表面的糖蛋白配体密度。通过特异于流感病毒的等离子信号检测探针的结合。
• VIRUS DETECTION
  申请人：UNIVERSITY OF EAST ANGLIA

  公开号：US20160185814A1

  公开（公告）日：2016-06-30

  The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus—for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

  该发明提供了用于检测流感病毒的方法和材料，利用纳米颗粒，例如金纳米颗粒，探针包括多种糖蛋白配体，每个糖蛋白配体（GL）具有多种含有唾液酸识别基团（Y）的识别基团，通过多价核心（X）与纳米颗粒耦合，其中多价核心（X）是三价核心，因此每个配体有3个识别基团，生物共轭物上的识别基团特异性地结合到目标流感病毒上的血凝素。探针可以包括进一步与纳米颗粒结合的配基，不特异性地结合到流感病毒，例如聚乙二醇基团。这些可以调节纳米颗粒表面的糖蛋白配体密度。探针的结合通过等离子体信号检测，该信号特异性地与流感病毒相关。
• Virus detection
  申请人：ICENI DIAGNOSTICS LIMITED

  公开号：US10174069B2

  公开（公告）日：2019-01-08

  The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe comprising a plurality of glycoconjugate ligands, each glyconjugate ligand (GL) having a plurality of sialic-acid containing recognition group (Y) coupled to the nanoparticle via a multivalent core (X), wherein the multivalent core (X) is a trivalent core, whereby there are 3 recognition groups per ligand, wherein the recognition groups on the bioconjugate specifically bind to the hemagglutinin on the target influenza virus. The probes may include further ligands bound to the nanoparticle which do not bind specifically to an influenza virus—for example polyethylene glycol groups. These can modulate density of the glycoconjugate ligand on the surface of the nanoparticle. Binding of probes is detected by a plasmonic signal which is specific to the influenza virus.

  本发明提供了用于检测流感病毒的方法和材料，该方法和材料利用纳米粒子，例如金纳米粒子，探针包括多个糖结合配体，每个糖结合配体(GL)具有多个含硅烷基酸的识别基团(Y)，通过多价核(X)与纳米粒子耦合、其中多价核（X）是三价核，即每个配体有 3 个识别基团，其中生物共轭物上的识别基团与目标流感病毒上的血凝素特异性结合。探针可包括与纳米粒子结合的其他配体，这些配体不与流感病毒特异性结合--例如聚乙二醇基团。这些配体可以调节纳米粒子表面糖结合配体的密度。探针的结合可通过与流感病毒特异的等离子信号检测到。
• IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING THE SAME
  申请人：Kajihara Yasuhiro

  公开号：US20110313136A1

  公开（公告）日：2011-12-22

  A full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto, and a process for producing the full-length IgG-Fc fragment. Specifically, an IgG-Fc fragment has a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1st to 30th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met reside is substituted by an amino acid reside other than a Met residue.
• 2,3-Fluorinated Glycosides as Neuraminidase Inhibitors and Their Use as Anti-Virals
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20150158899A1

  公开（公告）日：2015-06-11

  Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.