α-N-acetylaminocinnamamide | 38243-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-N-acetylaminocinnamamide
• 英文别名: α-Acylaminozimtsaeureamid；α-acetylamino-cinnamic acid amide；α-Acetylamino-zimtsaeure-amid；α-Acetamino-cinnamamid；α-Acetamino-zimtsaeure-amid；2-Acetylamino-3-phenylprop-2-enamide；2-acetamido-3-phenylprop-2-enamide
• CAS: 38243-38-8
• 化学式: C₁₁H₁₂N₂O₂
• mdl: MFCD24388957
• 分子量: 204.228
• InChiKey: CGSKTFVSAVYFAX-UHFFFAOYSA-N

物化性质

• 熔点：
  205 °C (decomp)
• 沸点：
  526.9±50.0 °C(Predicted)
• 密度：
  1.201±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-N-acetylaminocinnamamide 在 formamide 、 溶剂黄146 、 二乙胺 、 苯 作用下， 生成 5-benzylidene-2-styryl-3,5-dihydro-imidazol-4-one
  参考文献：
  名称：

  Pfleger; Markert, Chemische Berichte, 1957, vol. 90, p. 1494,1498

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-4-(苯基亚甲基)噁唑-5(4h)-酮 在 乙醇 、 氨 作用下， 生成 α-N-acetylaminocinnamamide
  参考文献：
  名称：

  Perceived work stress, overcommitment, and self-reported musculoskeletal pain: Across-sectional investigation

  摘要：

  The objective of this study was to analyze associations of three indicators of perceived work stress (physical job demand, low control at work, and an imbalance between effort and reward), and of overcommitment, a personal pattern of coping with work demands, with musculoskeletal pain. A standardized questionnaire measuring these conditions in addition to self-reported musculoskeletal pain at different locations was administered to a group of 316 male and female employees of a public transport enterprise. After we adjusted for confounding effects of age, sex, socioeconomic status, shift work, and negative affectivity, we observed elevated prevalence odds ratios in employees who scored high on overcommitment, who were exposed to physical job demand, and, to a lesser extent, who reported psychosocial work stress. Results have implications for a more comprehensive approach to primary and secondary prevention of musculoskeletal pain.

  DOI：

  10.1207/s15327558ijbm0902_04

文献信息

• THE ASYMMETRIC HYDROGENATION OF THE α-<i>N</i>-ACETYLAMINOCINNAMOYL DERIVATIVE OF AMINO ACIDS WITH CHIRAL BISPHOSPHINE–RHODIUM COMPLEX
  作者：Ken-ichi Onuma、Tomiyasu Ito、Asao Nakamura

  DOI：10.1246/cl.1980.481

  日期：1980.5.5

  An optical yield of the dipeptide obtained in the title reaction is affected by a chiral amino acid moiety in the substrate.

  在标题反应中获得的二肽的光学产率受底物中手性氨基酸部分的影响。
• Kjaer, Acta Chemica Scandinavica (1947), 1953, vol. 7, p. 889,896
  作者：Kjaer

  DOI：——

  日期：——