(2,4-Dihydroxy-3,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,4-Dihydroxy-3,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate
• 化学式: C₆H₁₆O₁₈P₄
• 分子量: 500.08
• InChiKey: CIPFCGZLFXVXBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.1
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  308
• 氢给体数：
  10
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  (3-benzoyloxy-2,4,5,6-tetrahydroxycyclohexyl) benzoate 生成 (2,4-Dihydroxy-3,5,6-triphosphonooxycyclohexyl) dihydrogen phosphate
  参考文献：
  名称：

  MEEK, JAMES L.;DAVIDSON, FRED;HOBBS, FRANK W. , JR., J. AMER. CHEM. SOC., 110,(1988) N 7, 2317-2318

  摘要：

  DOI：

文献信息

• SHIP1 MODULATORS AND METHODS RELATED THERETO
  申请人：Mackenzie Lloyd

  公开号：US20110136802A1

  公开（公告）日：2011-06-09

  Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

  结构化合物（I）：包括其立体异构体和药学上可接受的盐，其中X，R1，R2，R3，R4，R5，R6和R7如本文所定义。这些化合物具有作为SHIP1调节剂的活性，因此可以用于治疗任何需要SHIP1调节的各种疾病、疾病或情况。还公开了包含结构化合物（I）与药学上可接受的载体或稀释剂组合的组合物，以及通过向需要的动物施用这些化合物来进行SHIP1调节的方法。
• [EN] SHIP 1 MODULATORS<br/>[FR] MODULATEURS DE SHIP 1
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2004035601A1

  公开（公告）日：2004-04-29

  The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP I activity and methods of synthesis thereof.

  本发明涉及使用Pelorol、相关化合物及其制药组合物作为SHIP 1活性调节剂。本发明还提供了能够调节SHIP I活性的新型萜烯化合物及其合成方法。
• Regulation of ins(3456)p4 signalling by a reversible kinase phosphatase and methods and compositions related thereto
  申请人：Shears B Stephen

  公开号：US20060035810A1

  公开（公告）日：2006-02-16

  Provided is a method of increasing 3,4,5,6-tetrakisphosphate by increasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase, and a method of decreasing 3,4,5,6-tetrakisphosphate by decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase. A method of reducing salt, fluid or mucous secretion in a subject, comprising increasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in the subject is provided. A method of treating a disease that is exacerbated by salt, fluid or mucous secretion is also provided, comprising increasing the activity of inositol 1,3,4,5,6 pentakisphosphate phosphatase in a subject having a disease that is exacerbated by mucous, whereby mucous secretion is reduced and the disease is treated. Also provided is method of increasing salt and fluid secretion in a subject, comprising decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in the subject. A method of treating a disease that is treated by increased salt and fluid secretion is provided, comprising decreasing the activity of inositol 1,3,4,5,6 pentakisphosphate 1-phosphatase in a subject having a disease that is treated by increased salt and fluid secretion, whereby salt and fluid secretion is increased and the disease is treated.

  提供了一种通过增加肌醇1,3,4,5,6五磷酸1-磷酸酶的活性来增加3,4,5,6四磷酸盐的方法，以及通过降低肌醇1,3,4,5,6五磷酸1-磷酸酶的活性来减少3,4,5,6四磷酸盐的方法。提供了一种在受试对象中减少盐、液体或黏液分泌的方法，包括增加受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性。还提供了一种治疗因盐、液体或黏液分泌加重的疾病的方法，包括增加患有因黏液分泌加重的疾病的受试对象中肌醇1,3,4,5,6五磷酸磷酸酶的活性，从而减少黏液分泌并治疗疾病。还提供了一种在受试对象中增加盐和液体分泌的方法，包括降低受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性。提供了一种治疗因增加盐和液体分泌而治疗的疾病的方法，包括降低因增加盐和液体分泌而治疗的疾病的受试对象中肌醇1,3,4,5,6五磷酸1-磷酸酶的活性，从而增加盐和液体分泌并治疗疾病。
• PHARMACEUTICAL COMPOSITIONS AND FORMULATIONS INCLUDING INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Kirkpatrick D. Lynn

  公开号：US20120189670A1

  公开（公告）日：2012-07-26

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文描述了与Pleckstrin同源结构域结合的化合物，包括这些化合物的药物组合物，以及其使用方法。
• SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
  申请人：Mahadevan Daruka

  公开号：US20110144066A1

  公开（公告）日：2011-06-16

  Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

  本文描述了Pleckstrin homology domain结合化合物、包括这些化合物的制药组合物以及它们的使用方法。