p-Nitrophenyl-β-D-ribofuranose | 6892-58-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-Nitrophenyl-β-D-ribofuranose
• 英文别名: (2R,3S,4R)-2-(hydroxymethyl)-5-(4-nitrophenoxy)oxolane-3,4-diol
• CAS: 6892-58-6；22796-65-2；59495-69-1；99676-56-9
• 化学式: C₁₁H₁₃NO₇
• 分子量: 271.227
• InChiKey: DUYYBTBDYZXISX-QHPFDFDXSA-N

物化性质

• 沸点：
  553.7±50.0 °C(Predicted)
• 密度：
  1.562±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• ENZYME DETECTION/ASSAY METHOD AND SUBSTRATES
  申请人：——

  公开号：US20010019823A1

  公开（公告）日：2001-09-06

  The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a chromophore or a compound readily converted to a chromophore and the substrates are hydrolysed by the nucleoside hydrolase to yield ribose or 2-deoxyribose plus Y—OH. Alternatively those substrates may be phosphorylysed by nucleoside phosphorylase to yield ribose-1-phosphate plus Y—OH. The methods may be used to detect and/or assay parasites in biological samples.

  该发明涉及一种使用显色底物检测和/或测定核苷水解酶或核苷酸磷酸酶的方法。首选的显色底物具有式(I)，其中X为OH或H，Y为Y—OH的残基，其中Y—OH为色团或易于转化为色团的化合物，这些底物通过核苷水解酶水解产生核糖或2-脱氧核糖以及Y—OH。或者这些底物可能被核苷酸磷酸酶磷酸化产生核糖-1-磷酸加Y—OH。这些方法可用于检测和/或测定生物样本中的寄生虫。
• Inhibitors of nucleoside metabolism
  申请人：——

  公开号：US20020061898A1

  公开（公告）日：2002-05-23

  The present invention provides novel nucleoside-analogue compounds that are effective inhibitors of purine nucleoside phosphorylase (PNP), purine phosphoribosyltransferases (PPRT), and/or nucleoside hydrolases. Also provided are tautomers, esters, prodrugs, and pharmaceutically-acceptable salts of the compounds disclosed herein. The present invention further provides the use of these compounds as pharmaceuticals. The present invention also discloses pharmaceutical compositions containing these compounds. Finally, the present invention provides processes for preparing these compounds.

  本发明提供了新型核苷类似物化合物，它们是嘌呤核苷酸磷酸酶（PNP）、嘌呤磷酸核糖转移酶（PPRT）和/或核苷水解酶的有效抑制剂。此外，还提供了这些化合物的互变异构体、酯、前药和药学上可接受的盐。本发明进一步提供了这些化合物作为药物的用途。本发明还揭示了含有这些化合物的制药组合物。最后，本发明提供了制备这些化合物的过程。
• Enzyme detection/assay method and substrates
  申请人：——

  公开号：US20020132263A1

  公开（公告）日：2002-09-19

  The invention relates to a method of detecting and/or assaying nucleoside hydrolases or nucleoside phosphorylases using a chromogenic substrate. Preferred chromogenic substrates have formula (I) where X is OH, or H, and Y is the residue of Y—OH where Y—OH is a chromophore or a compound readily converted to a chromophore and the substrates are hydrolysed by the nucleoside hydrolase to yield ribose or 2-deoxyribose plus Y—OH. Alternatively those substrates may be phosphorylysed by nucleoside phosphorylase to yield ribose-1-phosphate plus Y—OH. The methods may be used to detect and/or assay parasites in biological samples. 1

  本发明涉及使用显色底物检测和/或测定核苷酸酶或核苷酸磷酸酶的方法。首选显色底物具有公式（I），其中X是OH或H，Y是Y-OH残基，其中Y-OH是一种色团或易于转化为色团的化合物，底物通过核苷酸酶水解产生核糖或2-去氧核糖加上Y-OH。或者，这些底物可被核苷酸磷酸酶磷酸化，形成核糖1-磷酸加上Y-OH。该方法可用于检测和/或测定生物样品中的寄生虫。
• INHIBITORS OF NUCLEOSIDE METABOLISM
  申请人：ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY

  公开号：EP1023308B1

  公开（公告）日：2005-09-07
• US5985848A
  申请人：——

  公开号：US5985848A

  公开（公告）日：1999-11-16