(S)-4-(tert-butoxy)-5-methyl-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one | 1316848-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (S)-4-(tert-butoxy)-5-methyl-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one
• 英文别名: (2S)-2-methyl-3-[(2-methylpropan-2-yl)oxy]-1-[(3S)-pyrrolidin-3-yl]-2H-pyrrol-5-one
• CAS: 1316848-17-5
• 化学式: C₁₃H₂₂N₂O₂
• 分子量: 238.33
• InChiKey: UZBJOYUGVWUPII-UWVGGRQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-4-(tert-butoxy)-5-methyl-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one 在 三氟乙酸 、 原甲酸三甲酯 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 22.0h， 生成 (S)-4-(tert-butoxy)-5-methyl-1-((S)-1-((S)-2-methyl-1-((S)-1-((S)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

  摘要：

  Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.

  DOI：

  10.1021/ja2033734
• 作为产物：
  描述：

  L-丙氨酸叔丁酯盐酸盐 在 盐酸 、 palladium 10% on activated carbon 、 氢气 、 sodium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 、 氯仿 、 异丙醇 为溶剂， -78.0~75.0 ℃ 、101.33 kPa 条件下， 反应 15.17h， 生成 (S)-4-(tert-butoxy)-5-methyl-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics

  摘要：

  Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.

  DOI：

  10.1021/ja2033734

文献信息

• PEPTIDOMIMETIC COMPOUNDS AND RELATED METHODS
  申请人：Burgess Kevin

  公开号：US20130288331A1

  公开（公告）日：2013-10-31

  Provided herein are compounds and methods of using same for the perturbation and/or inhibition of protein-protein interactions. Also provided herein is a data mining method useful for the identification of protein-protein interactions that may be inhibited by these compounds.
• Pyrrolinone–Pyrrolidine Oligomers as Universal Peptidomimetics
  作者：Arjun Raghuraman、Eunhwa Ko、Lisa M. Perez、Thomas R. Ioerger、Kevin Burgess

  DOI：10.1021/ja2033734

  日期：2011.8.17

  Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/beta-turn/sheet motif.