D-Mycamicose | 7474-30-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Mycamicose
• 英文别名: Mycuminose；Mycaminose；D-Mycaminose；3,6-Dideoxy-3-(dimethylamino)hexopyranose；4-(dimethylamino)-6-methyloxane-2,3,5-triol
• CAS: 7474-30-8
• 化学式: C₈H₁₇NO₄
• 分子量: 191.227
• InChiKey: DIOQKPOBSJVSJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  73.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Synthesis of desosamines
  申请人：President and Fellows of Harvard College

  公开号：US10544182B2

  公开（公告）日：2020-01-28

  The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

  本发明提供脱糖胺和霉菌胺糖类似物和硝基糖及其制备方法。本发明还提供了式(A′)化合物与乙二醛环化得到式(B)硝基糖的方法。本发明提供了制备式(D′)化合物的方法，包括硝基醇环化得到硝基糖，硝基糖还原和烷基化得到脱糖胺、霉菌胺糖或其类似物。
• INJECTABLE COMPOSITIONS FOR THE CONTROLLED DELIVERY OF PHARMACOLOGICALLY ACTIVE COMPOUND
  申请人：IDEXX LABORATORIES, INC.

  公开号：EP1446103B1

  公开（公告）日：2015-12-23
• SYNTHESIS OF DESOSAMINES
  申请人：President and Fellows of Harvard College

  公开号：US20180111956A1

  公开（公告）日：2018-04-26

  The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.