5′-bromo-1′-ethyl-3′-hydroxy-1′,3′-dihydro-1H,2′H-3,3′-biindol-2′-one | 676612-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5′-bromo-1′-ethyl-3′-hydroxy-1′,3′-dihydro-1H,2′H-3,3′-biindol-2′-one
• 英文别名: 5-bromo-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indolin-2-one；5-bromo-1-ethyl-3-hydroxy-3-(1H-indol-3-yl)indol-2-one
• CAS: 676612-44-5
• 化学式: C₁₈H₁₅BrN₂O₂
• 分子量: 371.233
• InChiKey: DIGOTGCFXABMLN-UHFFFAOYSA-N

物化性质

• 沸点：
  661.0±55.0 °C(Predicted)
• 密度：
  1.600±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  56.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吲哚 、 5-溴-1-乙基-1H-吲哚-2,3-二酮 在 sodium bromide 作用下， 以 丙醇 为溶剂， 以89%的产率得到5′-bromo-1′-ethyl-3′-hydroxy-1′,3′-dihydro-1H,2′H-3,3′-biindol-2′-one
  参考文献：
  名称：

  Electro-organic synthesis of nanosized particles of 3-hydroxy-3-(1H-indol-3-yl)indolin-2-one derivatives

  摘要：

  This article describes an electrochemical method for preparation of nanosized particles of 3-hydroxyoxindoles. The method is based on the reaction of isatins with indoles in propanol employing an undivided cell in the presence of NaBr as an electrolyte. The product was characterized after purification using infrared (IR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, mass spectrometry (MS), and scanning electron microscopy (SEM)..

  DOI：

  10.1007/s00706-011-0693-1

文献信息

• US8946283B2
  申请人：——

  公开号：US8946283B2

  公开（公告）日：2015-02-03
• Electro-organic synthesis of nanosized particles of 3-hydroxy-3-(1H-indol-3-yl)indolin-2-one derivatives
  作者：S. Makarem、A. R. Fakhari、A. A. Mohammadi

  DOI：10.1007/s00706-011-0693-1

  日期：2012.8

  This article describes an electrochemical method for preparation of nanosized particles of 3-hydroxyoxindoles. The method is based on the reaction of isatins with indoles in propanol employing an undivided cell in the presence of NaBr as an electrolyte. The product was characterized after purification using infrared (IR), H-1 nuclear magnetic resonance (NMR), C-13 NMR, mass spectrometry (MS), and scanning electron microscopy (SEM)..