3,11-Bis(hydroxymethyl)-4,7,12,14-tetraoxadispiro[4.2.48.25]tetradecane-1,2,9,10-tetrol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,11-Bis(hydroxymethyl)-4,7,12,14-tetraoxadispiro[4.2.48.25]tetradecane-1,2,9,10-tetrol
• 化学式: C₁₂H₂₀O₁₀
• 分子量: 324.28
• InChiKey: DKOQIDXJOZQKIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  158
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• Cell-Mediated Directed Evolution
  申请人：Cornish Virginia W.

  公开号：US20090209038A1

  公开（公告）日：2009-08-20

  The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most ‘fit’ mutants.
• US9169481B2
  申请人：——

  公开号：US9169481B2

  公开（公告）日：2015-10-27