cohumulone | 142628-20-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cohumulone
• 英文别名: 3,5,6-trihydroxy-4,6-bis(3-methylbut-2-enyl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one
• CAS: 142628-20-4
• 化学式: C₂₀H₂₈O₅
• 分子量: 348.439
• InChiKey: DRSITEVYZGOOQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cohumulone 在 acetate buffer 作用下， 以 乙醇 为溶剂， 生成 isocohumulone
  参考文献：
  名称：

  Isomerization and Degradation Kinetics of Hop (Humulus lupulus) Acids in a Model Wort-Boiling System

  摘要：

  The rate of isomerization of alpha acids to iso-alpha acids (the compounds contributing bitter taste to beer) was determined across a range of temperatures (90-130 degrees C) to characterize the rate at which iso-alpha acids are formed during kettle boiling. Multiple 12 mL stainless steel vessels were utilized to heat samples (alpha acids in a pH 5.2 buffered aqueous solution) at given temperatures, for varying lengths of time. Concentrations of alpha acids and iso-alpha acids were quantified by high-pressure liquid chromatography (HPLC). The isomerization reaction was found to be first order, with reaction rate varying as a function of temperature. Rate constants were experimentally determined to be k(1) = (7.9 x 10(11)) e((-1858/T)) for the isomerization reaction of alpha acids to iso-alpha acids, and k(2) = (4.1 x 10(12)) e((-12994/T)) for the subsequent loss of iso-alpha acids to uncharacterized degradation products. Activation energy was experimentally determined to be 98.6 kJ per mole for isomerization, and 108.0 U per mole for degradation. Losses of iso-alpha acids to degradation products were pronounced for cases in which boiling was continued beyond two half-lives of alpha-acid concentration.

  DOI：

  10.1021/jf0481296

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Compositions comprising curcuminoids and either alpha or beta acids for use in the treatment of diabetes
  申请人：Metaproteomics, LLC

  公开号：EP2263663A1

  公开（公告）日：2010-12-22

  The present invention relates to the use of a first component selected from an alpha acid and a beta acid in the manufacture of a medicament for the treatment of diabetes.

  本发明涉及使用从α酸和β酸中选择的第一组分在制造治疗糖尿病药物中的应用。
• Compositions Exhibiting Inhibition Of Cyclooxygenase-2
  申请人：Babish John G.

  公开号：US20090274778A1

  公开（公告）日：2009-11-05

  The invention provides a method of treating diabetes by administering to an individual having diabetes a composition containing a hops extract. In a particular embodiment, an individual having diabetes can be administered a composition comprising a first component selected from the group consisting of alpha acids and beta acids, essential oils, fats and waxed, with the proviso that the first component and second component are not the same compound. The invention additional provides a method of treating diabetes by administering to an individual having diabetes a composition comprising a first component selected from a curcuminoid and a second component selected from an alpha acid and a beta acid.

  本发明提供了一种通过向患有糖尿病的个体给予含啤酒花提取物的组合物来治疗糖尿病的方法。在一个特定的实施例中，可以向患有糖尿病的个体给予一种组合物，其中包括来自阿尔法酸和贝塔酸、精油、脂肪和蜡的第一成分，但第一成分和第二成分不是相同的化合物。本发明还提供了一种通过向患有糖尿病的个体给予包括姜黄素类化合物和阿尔法酸和贝塔酸中的第二成分的组合物来治疗糖尿病的方法。
• METHOD FOR SELECTING HOP LINE AND BREEDING MARKER AND PRIMER SET USED FOR SELECTING HOP LINE
  申请人：Okada Yukio

  公开号：US20100279284A1

  公开（公告）日：2010-11-04

  It is an object of the invention to screen for hop varieties with low cohumulone ratio and low colupulone ratio, as well as hop varieties with high contents of farnesene and/or linalool within a short time period utilizing a molecular screening method that employs a breeding marker. The invention provides a breeding marker using a polymorphism at the position of the 623rd nucleotide or a polymorphism at the position of the 1820th nucleotide of a polynucleotide consisting of the nucleotide sequence as set forth in SEQ ID NO: 5.

  本发明的目的是利用分子筛选方法筛选出具有低共螺烯比和低共葫芦烯比以及高芳烃和/或芳樟醇含量的啤酒花品种，并利用育种标记在短时间内进行筛选。本发明提供了一种育种标记，使用在由SEQ ID NO:5所述的核苷酸序列组成的多核苷酸中，第623个核苷酸位置或第1820个核苷酸位置上的多态性。