1,4-dihydroxy-3,5-bis[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-dihydroxy-3,5-bis[(3,4,5-trihydroxybenzoyl)oxy]cyclohexane-1-carboxylic acid
• 化学式: C₂₁H₂₀O₁₄
• 分子量: 496.381
• InChiKey: DYIWTUWURQKJDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  252
• 氢给体数：
  9
• 氢受体数：
  14

文献信息

• COMBINATION OF COMPOUNDS DERIVED FROM GALLIC ACID FOR THE TREATMENT OF CANCER
  申请人：FIORENTINO Susana

  公开号：US20150313925A1

  公开（公告）日：2015-11-05

  The invention relates to a combination of compounds derived from gallic acid, with an antitumoral and antimetastatic activity via a mechanism that involves the induction of apoptosis and the immunogenic death of the tumour cells and the subsequent activation of the specific immune response. The invention also relates to a composition containing a combination of derivatives of gallic acid and pharmaceutically acceptable excipients for the production of useful medicaments in the treatment of cancer. The invention further relates to the use of said composition in a coadjuvant in conventional chemotherapy, reducing the doses of chemptherapeutic agents used in the treatment of cancer.

  该发明涉及一种由没食子酸衍生的化合物组合，具有抗肿瘤和抗转移活性，通过诱导细胞凋亡和肿瘤细胞的免疫原性死亡以及后续激活特异性免疫应答的机制。该发明还涉及一种含有没食子酸衍生物组合和药用可接受的赋形剂的组合物，用于生产用于治疗癌症的有用药物。该发明进一步涉及在常规化疗中使用该组合物作为辅助剂，减少用于癌症治疗的化疗药物的剂量。
• US9931355B2
  申请人：——

  公开号：US9931355B2

  公开（公告）日：2018-04-03