3-[4-(3,4-Dihydroxyphenyl)-2-oxobut-3-enyl]-1,4,5-trihydroxycyclohexane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-[4-(3,4-Dihydroxyphenyl)-2-oxobut-3-enyl]-1,4,5-trihydroxycyclohexane-1-carboxylic acid
• 英文别名: 3-[4-(3,4-dihydroxyphenyl)-2-oxobut-3-enyl]-1,4,5-trihydroxycyclohexane-1-carboxylic acid
• 化学式: C₁₇H₂₀O₈
• 分子量: 352.3
• InChiKey: FFQSDFBBSXGVKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• EFFECTS OF A DECAFFEINATED GREEN COFFEE EXTRACT ON BODY WEIGHT CONTROL BY REGULATION OF GLUCOSE METABOLISM
  申请人：IBARRA Alvin

  公开号：US20150072042A2

  公开（公告）日：2015-03-12

  A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.