1-Methylamino-1-desoxy-L-arabit | 7115-47-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methylamino-1-desoxy-L-arabit
• 英文别名: 5-(Methylamino)pentane-1,2,3,4-tetrol
• CAS: 7115-47-1；7115-50-6；7185-78-6
• 化学式: C₆H₁₅NO₄
• 分子量: 165.189
• InChiKey: KYYOVZHUAVNUCN-UHFFFAOYSA-N

物化性质

• 沸点：
  401.0±45.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERGLYCEMIA AND METABOLIC SYNDROME
  申请人：Alapati Mohan Murali

  公开号：US20160318850A1

  公开（公告）日：2016-11-03

  The compositions and compounds of Formula I, Formula II, Formula III which includes a salts of polyunsaturated fatty acids in a molecular conjugate form with an amino acid L-leucine or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, nanoparticle, buccal administration or transdermal administration. Such compositions may be used to treatment of hyperglycemia, metabolic syndrome, diabetes, pre-diabetes, lowering triglycerides or its associated complications.

  Formula I、Formula II、Formula III的组合物和化合物包括多不饱和脂肪酸的盐，以分子共轭形式与氨基酸L-亮氨酸或其多晶形、对映异构体、立体异构体、溶剂合物和水合物结合。这些盐可以制成药物组合物。药物组合物可以制成口服、延迟释放或持续释放、经粘膜、糖浆、局部、肠道、注射、皮下、口服溶液、直肠给药、纳米颗粒、颊腔给药或经皮给药的制剂。这种组合物可用于治疗高血糖、代谢综合征、糖尿病、糖尿病前期、降低甘油三酯或其相关并发症。
• [EN] CONTRAST AGENTS<br/>[FR] AGENTS DE CONTRASTE
  申请人：BRACCO IMAGING SPA

  公开号：WO2017098038A1

  公开（公告）日：2017-06-15

  The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5

  本发明涉及一类新型的功能化大环化合物，能够螯合顺磁性金属离子，以及它们与金属离子形成的螯合络合物，以及将其用作对比剂的用途，特别适用于磁共振成像（MRI）分析。
• IMMUNOLOGICAL REAGENTS AND USES THEREFOR
  申请人：THE UNIVERSITY OF MELBOURNE

  公开号：US20150166542A1

  公开（公告）日：2015-06-18

  The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.

  本发明提供了一种能够与MR1结合的配体，其中该结合导致MR1与MAIT细胞的结合。
• Contrast agents
  申请人：BRACCO IMAGING S.P.A.

  公开号：US10781188B2

  公开（公告）日：2020-09-22

  The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

  本发明涉及能够螯合顺磁性金属离子的新型官能化大环化合物、其与金属离子的螯合复合物，以及将其用作造影剂，尤其适用于磁共振成像（MRI）分析。
• CONTRAST AGENTS
  申请人：Bracco Imaging SpA

  公开号：EP3386953B1

  公开（公告）日：2020-10-21