2-methyl-4-butylthiazole | 41981-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methyl-4-butylthiazole
• 英文别名: 4-butyl-2-methyl-thiazole；2-Methyl-4-butylthiazol；4-Butyl-2-methylthiazole；4-butyl-2-methyl-1,3-thiazole
• CAS: 41981-69-5
• 化学式: C₈H₁₃NS
• mdl: MFCD18451324
• 分子量: 155.264
• InChiKey: FKIYIWVSAZOGLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  硫代乙酰胺 、 1H-1-(1-Hexynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-dioxide 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以63%的产率得到2-methyl-4-butylthiazole
  参考文献：
  名称：

  Facile Preparation of Thiazoles from 1H-1-(1′-Alkynyl)-5-methyl-1,2,3-benziodoxathiole 3,3-Dioxide with Thioamides

  摘要：

  通过1H-1-(1′-炔基)-5-甲基-1,2,3-苯并碘氧硫杂环戊烷3,3-二氧化物与硫酰胺的反应，可以高产率地获得噻唑类化合物。这些1H-1-(1′-炔基)-5-甲基-1,2,3-苯并碘氧硫杂环戊烷3,3-二氧化物很容易通过1H-1-羟基-5-甲基-1,2,3-苯并碘氧硫杂环戊烷3,3-二氧化物与1-炔的反应制备得到。在此过程中，副产物——2-碘-5-甲基苯磺酸钾——通过简单过滤反应混合物即可定量回收，并可再生为1H-1-(1′-炔基)-5-甲基-1,2,3-苯并碘氧硫杂环戊烷3,3-二氧化物，再次用于相同噻唑的制备，保持良好的产率。

  DOI：

  10.1055/s-0028-1083439

文献信息

• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Ren Pingda

  公开号：US20120122838A1

  公开（公告）日：2012-05-17

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  调节激酶活性的化合物和药物组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和病况的化合物、药物组合物和治疗方法在此进行描述。
• [EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMERASE VIRALE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009018656A1

  公开（公告）日：2009-02-12

  Compound of Formula I: wherein, R2, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase

  化合物的化学式I：其中，R2、R5和R6如本文所定义，可用作乙型肝炎病毒NS5B聚合酶的抑制剂。
• SODIUM CHANNEL INHIBITORS
  申请人：Fulp Alan Bradley

  公开号：US20090023740A1

  公开（公告）日：2009-01-22

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  提供了在通过抑制电压门控钠通道中的钠离子通量来治疗疾病方面有用的化合物、组合物和方法。更具体地，本发明提供了取代磺胺基的化合物、包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或外周神经系统疾病的方法，特别是通过阻断与所示疾病的发作或复发相关的钠通道来治疗疼痛和慢性疼痛。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子通量来治疗神经病理性或炎症性疼痛。
• Potassium Channel Inhibitors
  申请人：Trotter B. Wesley

  公开号：US20090233897A1

  公开（公告）日：2009-09-17

  The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

  本发明涉及具有结构的化合物，可用作钾通道抑制剂以治疗心律失常等。
• Analogous compounds of 6-thioguanosine triphosphate, their use in medical fields and processes for their preparation
  申请人：Naccari Giancarlo

  公开号：US20090258837A1

  公开（公告）日：2009-10-15

  The invention relates to analogous compounds of 6-thioguanosine triphosphate of general formula (I). A compound of the general formula (I); wherein the dashed bond in the sugar moiety can be either single or double and wherein R1, R2, R3, R4 or R5, equal or different between each other, have general formula -(Int) m -Ter, wherein m is between 0 and 12 and Int and Ter are Internal and Terminal building blocks, wherein Int is selected from the group consisting of formula (II); and Ter is selected from the group consisting of formula (III). And wherein X represents either carbon or nitrogen atom within aromatic ring, Y represents either oxygen or sulphur atom and an additional group Q, group Qi or groups Qi (Qi indicates that the group or several groups may be bound to any unsaturated moiety of the ring) are selected from the group consisting of —OH, —COOH, —N(CH 3 ) 2 , —N(CH 2 —CH 3 ) 2 |—CO—CH 3 , —CO—O—CH 3 , —O—CH 3 , —S—CH 3 , —SO 2 —CH 3 , —CN, —NO 2 or -Halogen elements, and wherein R5 may be formula (IV) and metal and ammonium salts thereof, wherein n is between O and 5, or oxygen or phosphorus is partially or completely replaced by nitrogen, sulphur, methyleno groups or their derivatives. The invention also concerns the uses of the above mentioned compounds in medical field and the process for their preparation.

  本发明涉及6-硫鸟嘌呤三磷酸类似化合物，其通式为(I)。通式(I)的化合物中，糖基中的虚线键可以是单键或双键，其中R1、R2、R3、R4或R5，相互之间相同或不同，具有通式-(Int)m-Ter，其中m在0到12之间，Int和Ter是内部和末端构建块，其中Int从公式(II)所示的群组中选择；Ter从公式(III)所示的群组中选择。其中X代表芳香环内的碳或氮原子，Y代表氧或硫原子，以及附加基团Q、Qi基团或Qi基团（Qi表示该基团或若干基团可以结合到环的任何不饱和基团上）从以下群组中选择：—OH、—COOH、—N（CH3）2、—N（CH2—CH3）2、—CO—CH3、—CO—O—CH3、—O—CH3、—S—CH3、—SO2—CH3、—CN、—NO2或卤素元素，其中R5可以是公式(IV)及其金属和铵盐，其中n在0到5之间，或氧或磷部分或完全被氮、硫、亚甲基基团或其衍生物所取代。本发明还涉及上述化合物在医学领域中的用途以及它们的制备方法。