mannitol-1-phosphate | 13270-18-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: mannitol-1-phosphate
• 英文别名: 1-o-Phosphonohexitol；2,3,4,5,6-pentahydroxyhexyl dihydrogen phosphate
• CAS: 13270-18-3
• 化学式: C₆H₁₅O₉P
• 分子量: 262.153
• InChiKey: GACTWZZMVMUKNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.7
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  168
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS
  申请人：Virginia Tech Intellectual Properties, Inc.

  公开号：EP2291188A2

  公开（公告）日：2011-03-09
• TOPICAL ANTIVIRAL COMPOSITIONS
  申请人：Topical Remedy, LLC

  公开号：EP3344265A1

  公开（公告）日：2018-07-11
• [EN] COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR PROTÉGER DES CELLULES PAR LE BLOCAGE DE L'ENTRÉE DE PROTÉINES PATHOGÈNES
  申请人：VIRGINIA TECH INTELL PROP

  公开号：WO2009143133A2

  公开（公告）日：2009-11-26

  Pathogenic effector proteins which include one or more RxLR, dEER, Pexel or analogous motifs are blocked from entry into plant or animal cells by binding one or more of the motifs with a blocking compound which prevents binding of phosphoinositides or other polar lipids to the motifs which is a prerequisite for translocation of the pathogenic effector proteins into the plant or animal cell. The blocking compounds can take a variety of forms including synthetic peptides or the hydrophilic head-groups of phosphoinositides, phosphatidic acids, phospholipids, or sphingolipids. Suitable blocking compounds can be identified by assays demonstrating binding to RxLR, dEER, Pexel or analogous motifs. In addition, pathogenic effector proteins can be identified by analyzing whether they contain structural RxLR motifs using hidden markov modeling.
• [EN] COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PROTECTION DE CELLULES PAR BLOCAGE DE LA PÉNÉTRATION DE PROTÉINES PATHOGÈNES
  申请人：VIRGINIA TECH INTELL PROP

  公开号：WO2011060144A2

  公开（公告）日：2011-05-19

  Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B = RK or H; X = any amino acid or is absent; Z = L, M, I, W, Y or F) which bind to target polar lipids on a host (plant or animal) cell as a prerequisite for translocation of the pathogenic effector proteins into the cell. Translocation is prevented by binding blocking compounds to one or more motifs of the effector protein or to the lipid Iigands of the host cell. The blocking compounds include synthetic or naturally occurring polypeptides which bind the polar lipids or the motifs, various polar lipids, the hydrophilic head-groups of polar lipids, etc. Suitable blocking compounds can be identified by assays demonstrating binding to the motifs or to the target polar lipids.
• [EN] TOPICAL ANTIVIRAL COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIVIRALES TOPIQUES
  申请人：TOPICAL REMEDY LLC

  公开号：WO2017040844A1

  公开（公告）日：2017-03-09

  In various embodiments compositions that inactivates a virus or inhibit replication of a virus are provided where the compositions comprise a C1-C10 alcohol; an acid selected from the group consisting of gallic acid, methyl gallate, 3, 4-dihydroxy benzoic acid, p-hydroxy benzoic acid, vanillic acid, p-coumaric acid, ferulic acid, syringic acid, salicylic acid, luteic acid, and eudesmic acid; and a pharmaceutically acceptable carrier; where the pH of said composition is pH 4.5 or lower. In certain embodiments the alcohol comprises one or more alcohols selected from the group consisting of ethanol, ethanol, 2-propanol, 1-propanol, 2,3-butanediol, 1,2-butanediol, 1,3-butanediol, and 1,4-butanediol, butyl alcohol (including n-butanol, sec-butanol, isobutanol, tert-butanol), pentanol, hexadecan-1-ol, ethane-1,2-diol, propane-1,2-diol, propane-1,2,3-triol, butane-1,2,3,4-tetraol, pentane-1,2,3,4,5-pentol, hexane-1,2,3,4,5,6-hexol, heptane-1,2,3,4,5,6,7-heptol, prop-2-ene-1-ol, 3,7-dimethylocta-2,6-dien-1-ol, prop-2-in-1-ol, cyclohexane-1,2,3,4,5,6-hexol, and 2-(2-propyl)-5-methyl-cyclohexane-1-ol.