b-D-Ribofuranuronamide, 1-[6-(cyclopentylamino)-9H-purin-9-yl]-1-deoxy-N-ethyl-

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: b-D-Ribofuranuronamide, 1-[6-(cyclopentylamino)-9H-purin-9-yl]-1-deoxy-N-ethyl-
• 英文别名: 5-[6-(cyclopentylamino)purin-9-yl]-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
• 化学式: C₁₇H₂₄N₆O₄
• 分子量: 376.4
• InChiKey: GWVQGVCXFNYGFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• METHODS OF USING ADENOSINE A1 RECEPTOR ACTIVATION FOR TREATING DEPRESSION
  申请人：TUFTS UNIVERSITY

  公开号：US20140241990A1

  公开（公告）日：2014-08-28

  Disclosed herein are methods for treating depression and depressive-like symptoms by administering a therapeutically effective amount of an adenosine 1 receptor agonist. Also disclosed herein are methods for identifying adenosine receptor agonists and the use of identified adenosine receptor agonists for treating diseases, disorders or conditions characterized by pathological sleep perturbations.
• [EN] METHODS OF USING ADENOSINE A1 RECEPTOR ACTIVATION FOR TREATING DEPRESSION<br/>[FR] PROCÉDÉS D'UTILISATION DE L'ACTIVATION DU RÉCEPTEUR A1 DE L'ADÉNOSINE POUR LE TRAITEMENT DE LA DÉPRESSION
  申请人：UNIV TUFTS

  公开号：WO2013049725A2

  公开（公告）日：2013-04-04

  Disclosed herein are methods for treating depression and depressive-like symptoms by administering a therapeutically effective amount of an adenosine 1 receptor agonist. Also disclosed herein are methods for identifying adenosine receptor agonists and the use of identified adenosine receptor agonists for treating diseases, disorders or conditions characterized by pathological sleep perturbations.