[2-[Hydroxy(phosphonooxy)phosphoryl]oxy-3,4,5,6-tetraphosphonooxycyclohexyl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-[Hydroxy(phosphonooxy)phosphoryl]oxy-3,4,5,6-tetraphosphonooxycyclohexyl] phosphono hydrogen phosphate
• 化学式: C₆H₂₀O₃₀P₈
• 分子量: 820.0
• InChiKey: GXPFHIDIIMSLOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -12.5
• 重原子数：
  44
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  494
• 氢给体数：
  14
• 氢受体数：
  30

文献信息

• DRUG SCREENING SYSTEMS AND ASSAYS
  申请人：Cancer Research Technology Limited

  公开号：EP1283903A1

  公开（公告）日：2003-02-19
• Drug screening systems and assays
  申请人：——

  公开号：US20040029130A1

  公开（公告）日：2004-02-12

  A method of stimulating non-homologous end-joining (NHEJ) of DNA the method comprising performing NHEJ of DNA in the presence of inositol hexakisphosphate (IP 6 ) or other stimulatory inositol phosphate. An assay of a protein kinase wherein the assay comprises inositol hexakisphosphate (IP 6 ) or other stimulatory inositol phosphate. The invention also provides screening assays for compounds which may modulate NHEJ and which may be therapeutically useful; and screening assays for compounds which may modulate DNA-PK and related protein kinases and which may be therapeutically useful. Methods of modulating NHEJ and protein kinases are also disclosed.
• [EN] DRUG SCREENING SYSTEMS AND ASSAYS<br/>[FR] SYSTEMES ET METHODES DE CRIBLAGE DE MEDICAMENTS
  申请人：IMP CANCER RES TECH

  公开号：WO2001090404A1

  公开（公告）日：2001-11-29

  A method of stimulating non-homologous end-joining (NHEJ) of DNA the method comprising performing NHEJ of DNA in the presence of inositol hexakisphosphate (IP6) or other stimulatory inositol phosphate. An assay of a protein kinase wherein the assay comprises inositol hexakisphosphate (IP6) or other stimulatory inositol phosphate. The invention also provides screening assays for compounds which may modulate NHEJ and which may be therapeutically useful; and screening assays for compounds which may modulate DNA-PK and related protein kinases and which may be therapeutically useful. Methods of modulating NHEJ and protein kinases are also disclosed.