5,5-dimethyl-3-(2-thiosemicarbazonopropyl)tetrahydrofuran-2-one | 303965-77-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5,5-dimethyl-3-(2-thiosemicarbazonopropyl)tetrahydrofuran-2-one
• 英文别名: 5,5-Dimethyl-3-(2-thiosemicarbazonopropyl)-tetrahydrofuran-2-one；[1-(5,5-dimethyl-2-oxooxolan-3-yl)propan-2-ylideneamino]thiourea
• CAS: 303965-77-7
• 化学式: C₁₀H₁₇N₃O₂S
• 分子量: 243.33
• InChiKey: GVWJKWINDZCJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5,5-dimethyl-3-(2-oxopropyl)tetrahydrofuran-2-one 、 氨基硫脲 在 硫酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以80%的产率得到5,5-dimethyl-3-(2-thiosemicarbazonopropyl)tetrahydrofuran-2-one
  参考文献：
  名称：

  Synthesis of 5-substituted 3-(2-oxopropyl)tetrahydrofuran-2-ones and heterocyclic compounds on their base

  摘要：

  Alkylation of ethyl 2-oxotetrahydrofuran-3-carboxylates with 2,3-dichloroprop-1-ene and 3-bromoprop-1-yne gave new 3,5,5-tri- and 3,3,5,5-tetrasubstituted tetrahydrofuran-2-ones which were converted into the corresponding 3-(2-oxopropyl)tetrahydrofuran-2-ones. Reactions of the latter with semicarabazide, thiosemicarbazide, and phenylhydrazine were studied with a view to obtain new heterocyclic lactones.

  DOI：

  10.1134/s1070428008120130

文献信息

• Synthesis of 5-substituted 3-(2-oxopropyl)tetrahydrofuran-2-ones and heterocyclic compounds on their base
  作者：T. V. Kochikyan、E. V. Arutyunyan、V. S. Arutyunyan、A. A. Avetisyan

  DOI：10.1134/s1070428008120130

  日期：2008.12

  Alkylation of ethyl 2-oxotetrahydrofuran-3-carboxylates with 2,3-dichloroprop-1-ene and 3-bromoprop-1-yne gave new 3,5,5-tri- and 3,3,5,5-tetrasubstituted tetrahydrofuran-2-ones which were converted into the corresponding 3-(2-oxopropyl)tetrahydrofuran-2-ones. Reactions of the latter with semicarabazide, thiosemicarbazide, and phenylhydrazine were studied with a view to obtain new heterocyclic lactones.