5-Hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Hydroxy-7-oxabicyclo[4.1.0]hept-2-ene-3-carboxylic acid
• 化学式: C₇H₈O₄
• 分子量: 156.14
• InChiKey: HCJYBFJCLBWRFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• PROCESS FOR THE PREPARATION OF 7-AZABICYCLO 4.1.0]-HEPT-3-ENE-3-CARBOXYLIC ACID ESTERS
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1229022A1

  公开（公告）日：2002-08-07

  The present invention provides a method of producing 7-azabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester (VII) economically, industrially advantageously and efficiently in a large amount. The present invention relates to a production method of compound (VII), which includes reacting epoxide (I) with amine (II) to give aminodiol (III), reacting the aminodiol (III) with a sulfonylating agent in the presence of a base to give azabicyclohept-2-ene (IV), reacting the azabicyclohept-2-ene (IV) with alcohol (V) in the presence of a Lewis acid to give azabicyclohept-3-ene (VI), and eliminating the 7-position substituent R2 from the azabicyclohept-3-ene (VI).

  本发明提供了一种经济、工业化和高效地大量生产7-氮杂双环[4.1.0]庚-3-烯-3-羧酸酯(VII)的方法。本发明涉及一种化合物（VII）的生产方法，包括环氧化物（I）与胺（II）反应生成氨基二醇（III），氨基二醇（III）在碱存在下与磺化剂反应生成氮杂双环庚-2-烯（IV）、在路易斯酸存在下，使氮杂双环庚-2-烯（IV）与醇（V）反应，得到氮杂双环庚-3-烯（VI），并消除氮杂双环庚-3-烯（VI）上的 7 位取代基 R2。
• PROCESS FOR THE PRODUCTION OF 5-OXY-7-OXABICYCLO- 4.1.0]HEPT-3-E NE-3-CARBOXYLIC ACID ESTERS
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1245569A1

  公开（公告）日：2002-10-02

  The present invention provides a method of producing 5-oxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester economically, industrially advantageously and efficiently in a large amount. The present invention is a method of producing 5-oxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester (X), which is shown in the following scheme. wherein each symbol is as defined in the specification.

  本发明提供了一种经济、工业化和高效地大量生产5-氧-7-氧杂双环[4.1.0]庚-3-烯-3-羧酸酯的方法。本发明是一种生产 5-氧-7-氧杂双环[4.1.0]庚-3-烯-3-羧酸酯（X）的方法，其生产方案如下所示。 其中各符号如说明书中所定义。
• Endo-2,3-epoxy-7-oxabicylco[2.2.1]heptane-endo-5-carboxylic acid derivative
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1486499A1

  公开（公告）日：2004-12-15

  The present invention provides a method of producing 5-oxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester economically, industrially advantageously and efficiently in a large amount. The present invention is a method of producing 5-oxy-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester (X), which is shown in the following scheme. wherein each symbol is as defined in the specification.

  本发明提供了一种经济、工业化和高效地大量生产5-氧-7-氧杂双环[4.1.0]庚-3-烯-3-羧酸酯的方法。本发明是一种生产 5-氧-7-氧杂双环[4.1.0]庚-3-烯-3-羧酸酯（X）的方法，其生产方案如下所示。 其中各符号如说明书中所定义。
• PROCESS FOR THE PREPARATION OF 7-AZABICYCLO (4.1.0)-HEPT-3-ENE-3-CARBOXYLIC ACID ESTERS
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1229022B1

  公开（公告）日：2004-05-19
• US6790964B1
  申请人：——

  公开号：US6790964B1

  公开（公告）日：2004-09-14