7-Hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one
• 英文别名: 7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
• 化学式: C₁₉H₂₂O₉
• 分子量: 394.4
• InChiKey: HKIKAXXIWJHWLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• AQUEOUS COMPOSITION COMPRISING ACTIVE INGREDIENTS FOR THE DE-PIGMENTATION OF THE SKIN
  申请人：Univera Pharmaceuticals, Inc.

  公开号：EP1073418B1

  公开（公告）日：2007-12-05
• METHOD FOR EXTRACTING ALOESIN FROM ALOE BITTERS
  申请人：CSIR

  公开号：EP1874751B1

  公开（公告）日：2011-11-09
• Method for Converting Aloeresin a to Aloesin
  申请人：Steenkamp Lucia H.

  公开号：US20080280348A1

  公开（公告）日：2008-11-13

  The invention provides a process for hydrolytically converting aloeresin A to aloesin by the following reaction: The amount of aloesin available for extraction from sap of aloe plants is thereby increased and the extraction and purification of the aloesin is also made easier and less costly. As aloesin is more commercially valuable than aloeresin A, the process also increases the commercial value of the sap or aloe bitters from the aloe plant. The process optionally also includes the step of separating the aloesin from the p-coumaric acid. Typical hydrolysis steps that are used in the process are acid hydrolysis, base hydrolysis and enzymatic hydrolysis. In the case of acid hydrolysis, the acid is any suitable organic or inorganic acid, such as hydrochloric acid, sulfuric acid, nitric acid or phosphoric acid. In the case of enzymatic hydrolysis, the hydrolytic enzyme is typically an esterase, a lipase or a protease.
• Osmoprotective Complexes for Prevention of Intra-cellular Dehydration in Mammals
  申请人：GUPTA SHYAM K.

  公开号：US20110124573A1

  公开（公告）日：2011-05-26

  This invention relates to certain Aloesin derivatives with natural amino acids, peptides, and amino sugars (formula I). The compounds of the present invention possess osmoprotective properties, which are suitable for topical or oral application to treat dermatological disorders including challenged skin from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof:
• Osmoprotective Complexes for Prevention of Mitochondrial Free Radical Damage Related Skin Aging
  申请人：GUPTA SHYAM K.

  公开号：US20130028854A1

  公开（公告）日：2013-01-31

  The present invention discloses a method to inhibit a free radical, including a mitochondrial free radical, comprising administering to a subject in need thereof an effective amount of a composition comprising a compound of formula (I: a, b), an isomer, or a salt thereof: