3-[3,4-Bis(methoxymethoxy)phenyl]-1-[2-hydroxy-4,6-bis(methoxymethoxy)-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one | 650571-88-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-[3,4-Bis(methoxymethoxy)phenyl]-1-[2-hydroxy-4,6-bis(methoxymethoxy)-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
• CAS: 650571-88-3
• 化学式: C₂₈H₃₆O₁₀
• 分子量: 532.588
• InChiKey: HLKSAHAYZQZOGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  3-[3,4-Bis(methoxymethoxy)phenyl]-1-[2-hydroxy-4,6-bis(methoxymethoxy)-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 8-(3",3"-dimethylallyl)-5,7,3',4'-tetrakis(methoxymethoxy)flavanone
  参考文献：
  名称：

  Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents

  摘要：

  A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.120
• 作为产物：
  描述：

  3,4-双(甲氧基甲氧基)苯甲醛 、 2',4'-bis(methoxymethoxy)-5'-(3",3"-dimethylallyl)-6'-hydroxyacetophenone 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 生成 3-[3,4-Bis(methoxymethoxy)phenyl]-1-[2-hydroxy-4,6-bis(methoxymethoxy)-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
  参考文献：
  名称：

  Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents

  摘要：

  A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.120

文献信息

• Synthesis, biological evaluation of prenylflavonoids as vasorelaxant and neuroprotective agents
  作者：Xiaowu Dong、Lingling Qi、Chaoyi Jiang、Jing Chen、Erqing Wei、Yongzhou Hu

  DOI：10.1016/j.bmcl.2009.04.120

  日期：2009.6

  A series of prenylflavonoids with multiple hydroxyl groups were synthesized and evaluated for their vasorelaxant activities against rat aorta rings pre-contracted by phenylephrine (PE), as well as their neuroprotective effects against OGD induced PC12 cell injury. The results indicated that the prenyl group at A-ring of prenylflavonoids, as well as hydroxyl groups at B-ring was important for their activities. (+/-)Leachianone G 1b, bearing 8-prenyl and 2',4'-dihydoxyl groups, exhibited the most potent vasorelaxant and neuroprotective effects. (C) 2009 Elsevier Ltd. All rights reserved.