2-(α-D-glucopyranosyl)methyl-2,5,7,8-tetramethyl chroman-6-ol | 1050517-23-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(α-D-glucopyranosyl)methyl-2,5,7,8-tetramethyl chroman-6-ol
• 英文别名: Tetramethylchromanol glucoside；(2R,3S,4R,5R,6R)-2-(hydroxymethyl)-6-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methyl]oxane-3,4,5-triol
• CAS: 1050517-23-1
• 化学式: C₂₀H₃₀O₇
• 分子量: 382.454
• InChiKey: GFTUVGXUYWIPMI-BHMOCAHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• PROPHYLACTIC AND THERAPEUTIC AGENT FOR INFLAMMATORY INTESTINAL DISEASES
  申请人：CCI CORPORATION

  公开号：EP0965344A1

  公开（公告）日：1999-12-22

  A prophylactic and therapeutic agent for inflammatory intestinal diseases comprising as the active ingredient a chromanol glucoside represented by general formula (1), wherein R1, R2, R3, and R4, which may be the same or different, represent each a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group; X represents a monosaccharide residue or an oligosaccharide residue wherein the hydrogen atom(s) of the hydroxyl group(s) in the saccharide residue may be substituted with a lower alkyl group or a lower acyl group; n is an integer of 0 to 6; and m is an integer of 1 to 6. Since it contains as the active ingredient the chromanol glucoside which is soluble in water and possesses excellent antioxidation activity and anti-free radical activity, it can significantly prevent any pathological change in inflammatory intestinal diseases and markedly improve the pathology. Further, it can be made into an aqueous preparation containing the active ingredient in a high concentration and the aqueous preparation can effectively act in a small amount on the affected part to prevent or treat inflammatory intestinal diseases and, since no side effect accompanies, can be very safely used.

  一种肠道炎症性疾病的预防和治疗剂，其活性成分包括通式(1)代表的色醇葡萄糖苷，其中R1、R2、R3和R4可以相同或不同，各自代表氢原子或低级烷基；R5 代表氢原子、低级烷基或低级酰基； X 代表单糖残基或寡糖残基，其中糖残基中羟基的氢原子可被低级烷基或低级酰基取代； n 是 0 到 6 的整数；m 是 1 到 6 的整数。由于它的有效成分是可溶于水的色原醇葡萄糖苷，具有极佳的抗氧化活性和抗自由基活性，因此可以显著预防肠道炎症性疾病的病理变化，明显改善病理状况。此外，它还可以制成含有高浓度活性成分的水制剂，该水制剂只需少量就能有效地作用于患病部位，预防或治疗肠道炎症性疾病，而且由于没有副作用，使用非常安全。
• PREVENTIVES AND REMEDIES FOR ISCHEMIC REFLOW DISORDER
  申请人：CCI CORPORATION

  公开号：EP1066832A1

  公开（公告）日：2001-01-10

  An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: [wherein R1, R2, R3, and R4 independently denote a hydrogen atom or a lower alkyl group, R5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0 - 6, and m denotes an integer of 1 - 6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.

  本发明公开了一种用于预防和治疗缺血再灌注障碍的制剂，其活性成分为由下式通式表示的色醇苷： [其中，R1、R2、R3 和 R4 分别表示氢原子或低级烷基，R5 表示氢原子、低级烷基或低级酰基，X 表示单糖残基或低聚糖残基，其中糖残基羟基的氢原子可被低级烷基或低级酰基取代，n 表示 0-6 的整数，m 表示 1-6 的整数]。该制剂即使用量很少，也能安全有效地作用于受影响的部位，使心脏、胃、小肠、肝、脾、肾、脑和皮肤的缺血再灌注障碍以及内脏器官移植过程中的障碍得到预防和治愈。
• PREVENTIVE AND THERAPEUTIC AGENTS FOR ARTERIOSCLEROSIS
  申请人：CCI CORPORATION

  公开号：EP1151753A1

  公开（公告）日：2001-11-07

  This invention concerns an agent for preventing and curing arteriosclerosis, which has as an active component thereof a chromanol glucoside represented by the following general formula (1) (wherein R1, R2, R3, and R4 are the same or different and are each a hydrogen atom or a lower alkyl group, R5 is a hydrogen atom, a lower alkyl group, or a lower acyl group, X is a monosaccharide residue or an oligosaccharide residue optionally having a lower alkyl group or a lower acyl group substitute for the hydrogen atom of the hydroxyl group in the saccharide residue, n is an integer in the range of 0 - 6, and m is an integer in the range of 1 - 6). This agent is capable of effectively acting on the affected part safety at a small application rate and preventing and curing arteriosclerosis.

  本发明涉及一种预防和治疗动脉硬化的制剂，其活性成分是由下通式(1)代表的色烷醇葡糖苷 (其中 R1、R2、R3 和 R4 相同或不同，并且各自为氢原子或低级烷基，R5 为氢原子、低级烷基或低级酰基，X 为单糖残基或寡糖残基，可选择用低级烷基或低级酰基取代糖残基中羟基的氢原子，n 为 0-6 范围内的整数，m 为 1-6 范围内的整数）。这种药剂能够以较小的施用量有效地作用于受影响的安全部位，预防和治疗动脉硬化。
• SKIN PREPARATIONS FOR EXTERNAL USE
  申请人：CCI CORPORATION

  公开号：EP1174140A1

  公开（公告）日：2002-01-23

  An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, which may be the same or different, each represent a hydrogen atom or a lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group, X represents a monosaccharic residue or an oligosaccharic residue optionally having the hydrogen atom of the hydroxyl group in the saccharic residue substituted with a lower alkyl group or a lower acyl group, n represents an integer in the range of 0 - 6, and m represents an integer in the range of 1 - 6). This is a novel dermatological agent for external use which excels in stability and percutaneous absorbency, manifests an effective action safely at a small application rate, and effectively prevents and cures the dermopathy. It is very useful as an agent for preventing and curing the disorders caused by the ultraviolet light, an agent for preventing and allaying the sedimentation of pigment in the skin, an agent for beautifying the skin in white, an agent for preventing the senescence of the skin, an agent for activating cells, an agent for preventing and curing the dermopathy, and a cosmetic preparation.

  本发明公开了一种外用皮肤药剂，它含有由以下通式（1）代表的色烷醇苷 (其中 R1、R2、R3 和 R4（可以相同或不同）分别代表氢原子或低级烷基，R5 代表氢原子、低级烷基或低级酰基，X 代表单糖残基或低聚糖残基，其中糖残基中羟基的氢原子可选择被低级烷基或低级酰基取代，n 代表 0-6 范围内的整数，m 代表 1-6 范围内的整数）。这是一种新型的皮肤病外用制剂，它具有出色的稳定性和经皮吸收性，能在较小的用量下安全地发挥有效作用，并能有效地预防和治疗皮肤病。作为预防和治疗紫外线引起的疾病的药剂、预防和缓解皮肤色素沉淀的药剂、美白皮肤的药剂、预防皮肤衰老的药剂、活化细胞的药剂、预防和治疗皮肤病的药剂以及化妆品制剂，它都非常有用。
• AMELIORANT FOR CHEMICAL TREATMENT OF CANCER
  申请人：Kagiya, Tsutomu

  公开号：EP1488796A1

  公开（公告）日：2004-12-22

  An ameliorating agent for cancer chemotherapy is disclosed, which comprises a chromanol glucoside represented by the following general formula (1) (wherein R1, R2, R3, and R4, which are identical or different from each other, stand for a hydrogen atom or a lower alkyl group, R5 stands for a hydrogen atom, a lower alkyl group, or a lower acyl group, X stands for a monosaccharide residue or an oligosaccharide residue optionally having the hydrogen atom of the hydroxyl group in the saccharide residue substituted with a lower alkyl group or a lower acyl group, n is an integer in the range of 0 - 6, and m is an integer in the range of 1 - 6). According to this invention, a novel ameliorating agent for cancer chemotherapy is provided which acts safely and effectively in a small dosage to enhance the carcinostatic action of an anti-cancer agent in cancer chemotherapy and repressing side effects by cancer chemotherapy as well.

  本发明公开了一种用于癌症化疗的改善剂，它包括由以下通式(1)代表的色醇葡萄糖苷 (其中 R1、R2、R3 和 R4 代表氢原子或低级烷基，R5 代表氢原子、低级烷基或低级酰基、X 代表单糖残基或寡糖残基，其羟基的氢原子可选择被低级烷基或低级酰基取代，n 是 0-6 范围内的整数，m 是 1-6 范围内的整数）。 根据本发明，提供了一种用于癌症化疗的新型改善剂，它能以小剂量安全有效地增强癌症化疗中抗癌剂的抗癌作用，同时抑制癌症化疗的副作用。