1,3-diformyl-5-hydroxymethylbenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-diformyl-5-hydroxymethylbenzene
• 英文别名: 5-(Hydroxymethyl)benzene-1,3-dicarbaldehyde；5-(hydroxymethyl)benzene-1,3-dicarbaldehyde
• 化学式: C₉H₈O₃
• 分子量: 164.161
• InChiKey: ISZLCNAQEKYXOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-乙酰基吡啶 、 1,3-diformyl-5-hydroxymethylbenzene 在 sodium hydroxide 、 ammonium acetate 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 24.0h， 以23%的产率得到1,3-bis(2,2':6',2''-terpyridine-4'-yl)-5-(hydroxymethyl)benzene
  参考文献：
  名称：

  Hexagonal Terpyridine–Ruthenium and –Iron Macrocyclic Complexes by Stepwise and Self-Assembly Procedures

  摘要：

  Methods for the self-assembly, as well as directed construction, of hexaruthenium metallomacrocycles employing bisterpyridine building blocks are described. Self-assembly is effected by a combination of equimolar mixtures of bismetalated and nonmetalated bis(terpyridinyl) monomers each possessing the requisite planar, 60degrees, terpyridine-metal-terpyridine connectivity. Stepwise synthesis of the identical hexamer is also discussed and used to aid in verification of the self-assembled product. Preparation and analysis of the related Fe-II metallomacrocycle are detailed and its TEM image confirms the hexameric structure. Characterization of the metalated products includes cyclic voltammetry along with the routine analytical techniques.

  DOI：

  10.1002/1521-3765(20020703)8:13<2946::aid-chem2946>3.0.co;2-m
• 作为产物：
  描述：

  1,3,5-苯三甲酰氯 在 lithium tri(t-butoxy)aluminum hydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以33%的产率得到1,3-diformyl-5-hydroxymethylbenzene
  参考文献：
  名称：

  Hexagonal Terpyridine–Ruthenium and –Iron Macrocyclic Complexes by Stepwise and Self-Assembly Procedures

  摘要：

  Methods for the self-assembly, as well as directed construction, of hexaruthenium metallomacrocycles employing bisterpyridine building blocks are described. Self-assembly is effected by a combination of equimolar mixtures of bismetalated and nonmetalated bis(terpyridinyl) monomers each possessing the requisite planar, 60degrees, terpyridine-metal-terpyridine connectivity. Stepwise synthesis of the identical hexamer is also discussed and used to aid in verification of the self-assembled product. Preparation and analysis of the related Fe-II metallomacrocycle are detailed and its TEM image confirms the hexameric structure. Characterization of the metalated products includes cyclic voltammetry along with the routine analytical techniques.

  DOI：

  10.1002/1521-3765(20020703)8:13<2946::aid-chem2946>3.0.co;2-m

文献信息

• COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20150038512A1

  公开（公告）日：2015-02-05

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明涉及一种包含聚胺化合物的化合物、组合物和方法，可用于杀死、分散、治疗或减少生物膜，或抑制或大幅预防生物膜的形成。在某些方面，本发明涉及包含聚胺化合物的化合物、组合物和方法，其具有针对能够形成生物膜的各种细菌菌株的抗微生物或分散活性。
• Methods comprising a biocidal polyamine
  申请人：Curza Global, LLC

  公开号：US10440955B2

  公开（公告）日：2019-10-15

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明描述了包含多胺化合物的化合物、组合物和方法，这些化合物、组合物和方法可用于杀灭、分散、处理或减少生物膜，或用于抑制或基本防止生物膜的形成。在某些方面，本发明涉及包含多胺化合物的化合物、组合物和方法，这些化合物对能够形成生物膜的各种细菌菌株具有抗菌或分散活性。
• COMPOSITIONS AND METHODS COMPRISING A POLYAMINE
  申请人：Curza Global LLC

  公开号：EP2999345A1

  公开（公告）日：2016-03-30
• COMPOSITIONS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20160330962A1

  公开（公告）日：2016-11-17

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
• US9439433B2
  申请人：——

  公开号：US9439433B2

  公开（公告）日：2016-09-13