lithium tri(t-butoxy)aluminum hydride

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: lithium tri(t-butoxy)aluminum hydride
• 英文别名: lithium tri-tert-butoxyaluminohydride；lithium tri-t-butoxy-aluminohydride；lithium tris-tert-butoxyaluminohydride；lithium aluminum tri-tert-butoxyhydride；Lithium aluminum-tri-tert-butoxyhydride
• 化学式: C₁₂H₂₇AlO₃*Li
• 分子量: 253.267
• InChiKey: FMSXILLOKUGXFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.42
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lithium tri(t-butoxy)aluminum hydride 、 3-氯-2-羟基-苯甲酰氯 以 二乙二醇二甲醚 为溶剂， 生成 3 -氯- 2 -羟基苯
  参考文献：
  名称：

  Ortho-substituted aromatic ether compounds and their use in

  摘要：

  该发明提供了以下式I的化合物：##STR1## 其中A、B、D、X、R.sup.1和R.sup.3具有规范中定义的任何值，以及它们的N-氧化物、S-氧化物、药用盐以及体内可水解的酯和酰胺，这些化合物对缓解疼痛有用。该发明还提供了与这些化合物相关的药物组合物，以及合成和治疗方法。

  公开号：

  US05965741A1
• 作为试剂：
  描述：

  醋羟孕酮 在 Lindlar's catalyst lithium tri(t-butoxy)aluminum hydride 、 氢气 作用下， 以 吡啶 、 乙醚 为溶剂， 反应 24.0h， 生成 17α-acetoxy-3α-hydroxy-5β-pregnan-20-one
  参考文献：
  名称：

  Templeton, John F.; Kumar, V. P. Sashi; Kim, Ryungsoon S., Journal of the Chemical Society. Perkin transactions I, 1987, p. 1361 - 1368

  摘要：

  DOI：

文献信息

• [EN] HCV POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE LA POLYMÉRASE DU VHC
  申请人：MEDIVIR AB

  公开号：WO2015056213A1

  公开（公告）日：2015-04-23

  The invention provides compounds of the formula (I) wherein B is a nucleobase selected from the groups (a) to (d): and the other variables are as defined in the claims, which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.

  这项发明提供了公式（I）中的化合物，其中B是从（a）到（d）组中选择的核碱基：其他变量如索权中所定义，这些化合物可用于治疗或预防丙型肝炎病毒感染及相关方面。
• Polycyclic guanine derivatives
  申请人：Schering Corporation

  公开号：US05393755A1

  公开（公告）日：1995-02-28

  Novel polycylic guanine derivatives of the formula: ##STR1## wherein J is oxygen or sulfur, R.sup.1 is hydrogen, alkyl or alkyl substituted with aryl or hydroxy; R.sup.2 is hydrogen, aryl, heteroaryl, cycloalkyl, alkyl or alkyl substituted with aryl, heteroaryl, hydroxy, alkoxy, amino, monoalkyl amino or dialkylamino, or --(CH.sub.2).sub.m TCOR.sup.20 wherein m is an integer from 1 to 6, T is oxygen or --NH-- and R.sup.20 is hydrogen, aryl, heteroaryl, alkyl or alkyl substituted with aryl or heteroaryl; R.sup.3 is hydrogen, halo, trifluoromethyl, alkoxy, alkylthio, alkyl, cycloalkyl, aryl, aminosulfonyl, amino, monoalkylamino, dialkylamino, hydroxyalkylamino, aminoalkylamino, carboxy, alkoxycarbonyl or aminocarbonyl or alkyl substituted with awl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino; R.sup.a, R.sup.b, R.sup.c, and R.sup.d are defined in the specification; and n is zero or one. The compounds of formulas (I) and (I') are useful as antihypertensive, muscle relaxant and bronchodilating agents.

  新颖的多环鸟嘌呤衍生物的化学式为：##STR1## 其中J为氧或硫，R.sup.1为氢，烷基或烷基取代芳基或羟基；R.sup.2为氢，芳基，杂环芳基，环烷基，烷基或烷基取代芳基，杂环芳基，羟基，烷氧基，氨基，单烷基氨基或二烷基氨基，或--(CH.sub.2).sub.m TCOR.sup.20，其中m为1到6的整数，T为氧或--NH--，R.sup.20为氢，芳基，杂环芳基，烷基或烷基取代芳基或杂环芳基；R.sup.3为氢，卤素，三氟甲基，烷氧基，硫烷基，烷基，环烷基，芳基，氨基磺酰基，氨基，单烷基氨基，二烷基氨基，羟基烷基氨基，氨基烷基氨基，羧基，烷氧羰基或氨基羰基或烷基取代芳基，羟基，烷氧基，氨基，单烷基氨基或二烷基氨基；R.sup.a，R.sup.b，R.sup.c和R.sup.d在规范中有定义；n为零或一。化合物的化学式(I)和(I')可用作降压、肌肉松弛和扩张支气管剂。
• Steroids as neurochemical initiators of change in human blood levels of
  申请人：Pherin Corporation

  公开号：US06066627A1

  公开（公告）日：2000-05-23

  The invention relates to a method of altering the blood levels of LH or FSH in an individual. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  该发明涉及一种改变个体血液中LH或FSH水平的方法。该方法包括经鼻给药一种类固醇物质，该类固醇物质是一种人类嗅觉素，使得该嗅觉素结合到特定的神经上皮受体上。该类固醇或多种类固醇最好以含有一个或多个药用载体的制药组合物的形式给药。
• Aromatic amino ethers as pain relieving agents
  申请人：Zeneca Limited

  公开号：US05843942A1

  公开（公告）日：1998-12-01

  The present invention relates to compounds of formula (I), ##STR1## wherein A is an optionally substituted phenyl naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring carbon atoms or a bicyclic ring system, provided that the --CH(R.sup.3)N(R.sup.2)B--R.sup.1 and --OCH(R.sup.4 --)--D linking groups arm positioned in a 1,2 relationship to one another on ring carbon atoms and the ring atom positioned ortho to the --OCHR.sup.4 -- linking group (and therefore in the 3-position relative to the --CHR.sup.3 NR.sup.2 -- linking group) is not substituted; B is an optionally substituted ring system; D is an optionally substituted ring system; R.sup.1 is a variety of group as defined in the description; R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, phenylC.sub.1-3 alkyl or 5- or 6-membered heteroarylC.sub.1-3 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; R.sup.4 is hydrogen or C.sub.1-4 alkyl; and N-oxides of NR.sup.2 where chemically possible; and S-oxides of sulphur containing rings were chemically possible; and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof. Process for their preparation, intermediates in theirpreparation, their use as therapeutic agents and pharmaceutical compositions containing them.

  本发明涉及如下式(I)的化合物，其中A是一个可选择取代的苯基萘基、吡啶基、吡嗪基、吡啶啉基、嘧啶基、噻吩基、噻唑基、噁唑基、噻二唑基，具有至少两个相邻环碳原子或双环环系统的环，前提是--CH(R^3)N(R^2)B--R^1和--OCH(R^4)--D连接基位于环碳原子上呈1,2关系，并且位于与--OCHR^4--连接基相邻的环原子（因此相对于--CHR^3 NR^2--连接基位于3位置）未被取代；B是一个可选择取代的环系统；D是一个可选择取代的环系统；R^1是描述中定义的各种基团；R^2是氢、C_1-6烷基、C_2-6烯基、C_2-6炔基、苯基C_1-3烷基或5-或6-成员的杂环基C_1-3烷基；R^3是氢或C_1-4烷基；R^4是氢或C_1-4烷基；NR^2的N-氧化物在化学上可能；含硫环的S-氧化物在化学上可能；以及其药学上可接受的盐和体内可水解的酯和酰胺。其制备方法，制备中间体，用作治疗剂的用途以及含有它们的药物组合物。
• Steroids as neurochemical stimulators of the VNO to alleviate symptoms
  申请人：Pherin Corporation

  公开号：US06057439A1

  公开（公告）日：2000-05-02

  The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.

  该发明涉及一种缓解经前期综合征和焦虑症状的方法。该方法包括通过鼻腔给药一种类固醇物质，即一种人类呕吐素，使得呕吐素与特定的神经上皮受体结合。所述类固醇物质通常以含有一种或多种药用载体的药物组合物的形式给予。