1,1-diethyldithioacetal of L-arabinose | 875441-58-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-diethyldithioacetal of L-arabinose
• 英文别名: 1,1-diethyldithioacetal of D-xylose；Diethylmercaptal-D-arabinose；5,5-bis(ethylsulfanyl)pentane-1,2,3,4-tetrol
• CAS: 875441-58-0
• 化学式: C₉H₂₀O₄S₂
• mdl: MFCD06016811
• 分子量: 256.387
• InChiKey: IZQLWYVNJTUXNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1-diethyldithioacetal of L-arabinose 、 六乙基亚磷酸胺 以 吡啶 为溶剂， 以57%的产率得到1,1-diethyldithioacetal of 2,3:4,5-bis-O-diethylaminophosphinediyl L-arabinose
  参考文献：
  名称：

  Nabiullin, V. N.; Mukmenev, E. T.; Arbuzov, B. A., Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 9, p. 1804

  摘要：

  DOI：

文献信息

• Laulimalide Analogs and Uses Thereof
  申请人：Gallagher Jr M. Brian

  公开号：US20070287745A1

  公开（公告）日：2007-12-13

  The present invention provides compounds having formula I: and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 10 , q, t, X 0 , X 1 , A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.

  本发明提供具有公式I的化合物及其药学上可接受的衍生物，其中R1-R10、q、t、X0、X1、A、B、D、E、G、J、K、L、M和Z如本文中一般和在类别和子类别中所述，并且此外还提供其药物组合物以及使用它们治疗与细胞过度增殖相关的疾病的方法。
• NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO
  申请人：EMORY UNIVERSITY

  公开号：US20160220595A1

  公开（公告）日：2016-08-04

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

  本公开涉及含有至少一种硫醇、硫酮或硫醚的核苷酸和核苷治疗组合物及其在治疗传染病、病毒感染和癌症方面的用途。
• [EN] LAULIMALIDE ANALOGS AND USES THEREOF<br/>[FR] ANALOGUES DE LAULIMALIDE ET UTILISATIONS DE CEUX-CI
  申请人：EISAI CO LTD

  公开号：WO2005030779A2

  公开（公告）日：2005-04-07

  The present invention provides compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.