3-(12-hydroxyhexadecoxy)-5-methyl-3-oxo-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-(12-hydroxyhexadecoxy)-5-methyl-3-oxo-8,8a-dihydro-1H-furo[3,4-e][1,3,2]dioxaphosphepin-6-one
• 化学式: C₂₃H₄₁O₇P
• 分子量: 460.5
• InChiKey: JGTUCPMGHURLJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  31
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Treating mycobacterial infections with cyclipostins
  申请人：sanofi-aventis

  公开号：EP1894601A1

  公开（公告）日：2008-03-05

  The invention refers to the use of a compound of the formula (1) for the treatment of bacterial infections caused by mycobacteria and related microorganisms, such as tuberculosis, leprosy, nocardiosis, diphtheria, pulmonary mycobacterial infection, cutaneous mycobacterial infection, atypical mycobacterial infection and mycobacteriosis.

  本发明涉及式（1）化合物的用途 用于治疗由分枝杆菌和相关微生物引起的细菌感染，如结核病、麻风病、诺卡氏菌病、白喉、肺分枝杆菌感染、皮肤分枝杆菌感染、非典型分枝杆菌感染和分枝杆菌病。
• TREATING MYCOBACTERIAL INFECTIONS WITH CYCLIPOSTINS
  申请人：Sanofi-Aventis

  公开号：EP2059304B1

  公开（公告）日：2011-04-06
• USE OF CYCLIPOSTIN DERIVATIVES FOR THE TREATMENT OF MYCOBACTERIAL INFECTIOUS DISEASES
  申请人：SEIBERT Gerhard

  公开号：US20090233884A1

  公开（公告）日：2009-09-17

  The invention relates to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria and related microorganisms, such as tuberculosis, leprosy, nocardiosis, diphtheria, pulmonary mycobacterial infection, cutaneous mycobacterial infection, atypical mycobacterial infection and mycobacteriosis.
• US7923438B2
  申请人：——

  公开号：US7923438B2

  公开（公告）日：2011-04-12
• [EN] TREATING MYCOBACTERIAL INFECTIONS WITH CYCLIPOSTINS<br/>[FR] TRAITEMENT D'INFECTIONS MYCOBACTÉRIENNES AVEC DES CYCLIPOSTINES
  申请人：SANOFI AVENTIS

  公开号：WO2008025449A1

  公开（公告）日：2008-03-06

  [EN] The invention refers to the use of a compound of the formula (I) for the treatment of bacterial infections caused by mycobacteria and related microorganisms, such as tuberculosis, leprosy, nocardiosis, diphtheria, pulmonary mycobacterial infection, cutaneous mycobacterial infection, atypical mycobacterial infection and mycobacteriosis.
  [FR] L'invention concerne l'utilisation d'un composé de formule (I) destiné au traitement d'infections bactériennes provoquées par des mycobactéries et des microorganismes apparentés, telles que la tuberculose, la lèpre, la nocardiose, la diphtérie, l'infection mycobactérienne pulmonaire, l'infection mycobactérienne cutanée, l'infection mycobactérienne atypique et la mycobatériose.