Methoxy-ovin-sialinsaeure-methylester | 6730-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methoxy-ovin-sialinsaeure-methylester
• 英文别名: Methyl 5-acetamido-4-hydroxy-2-methoxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylate
• CAS: 6730-26-3；6730-43-4；99336-20-6；140195-54-6
• 化学式: C₁₃H₂₃NO₉
• 分子量: 337.327
• InChiKey: JKTJXQQVMKZKQA-UHFFFAOYSA-N

物化性质

• 熔点：
  181-182 °C
• 沸点：
  657.7±55.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Veronesi Paolo Alberto

  公开号：US20100029579A1

  公开（公告）日：2010-02-04

  The invention provides a new class of compounds exhibiting an inhibitory effect on neuraminidase (NA), hemagglutinin (HA) and structural M 2 protein bearing viruses. These compounds are also useful as inhibitors of the replication factors of hepatitis virus type C (HVC). The invention also describes pharmaceutical compositions containing the compounds of the invention either alone or in combination admixed with a suitable and pharmaceutically acceptable carrier.
• TREATMENT AND PROPHYLAXIS
  申请人：Levesque Jean-Pierre

  公开号：US20110002881A1

  公开（公告）日：2011-01-06

  This invention discloses the use of an E-selectin antagonist in methods and compositions for treating or preventing immunocompromised conditions resulting from medical treatment. The present invention is particular useful for prophylaxis and/or treatment of hematopoietic disorders including neutropenia, agranulocytosis, anemia and thrombocytopenia in individuals receiving or proposed to receive treatments that target rapidly dividing cells or that disrupt the cell cycle or cell division.
• GLYCOMIMETIC REPLACEMENTS FOR HEXOSES AND N-ACETYL HEXOSAMINES
  申请人：ERNST Beat

  公开号：US20110257380A1

  公开（公告）日：2011-10-20

  Compounds and methods are provided for obtaining oligosaccharide mimics. More specifically, compounds and methods are described wherein oligosaccharide mimics are obtained by incorporating or substituting in a cyclohexane derivative.
• METHODS OF USE OF GLYCOMIMETICS WITH REPLACEMENTS FOR HEXOSES AND N-ACETYL HEXOSAMINES
  申请人：MAGNANI John L.

  公开号：US20120202762A1

  公开（公告）日：2012-08-09

  Methods are provided for using a compound to treat, for example, endothelial dysfunction including vascular abnormalities. More specifically, methods are described for using an oligosaccharide compound or glycomimetic compound wherein a cyclohexane derivative is incorporated in either.
• COMPOSITIONS COMPRISING E-SELECTIN ANTAGONISTS AND USES THEREFOR
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US20160193294A1

  公开（公告）日：2016-07-07

  This invention discloses the use of an E-selectin antagonist and a mobilizer of hematopoietic stem cells or progenitor cells in methods and compositions for treating or preventing immunocompromised conditions resulting from medical treatment. The present invention is particular relevant for prophylaxis and/or treatment of hematopoeitic disorders including neutropenia, agranulocytosis, anemia and thrombocytopenia in individuals receiving or proposed to receive treatments that target rapidly dividing cells or that disrupt the cell cycle or cell division.