Dihydrolycoricidin-B | 34200-35-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 石蒜科生物碱
• 英文名称: Dihydrolycoricidin-B
• 英文别名: dihydrolycoricidine；2,3,4-trihydroxy-2,3,4,4a,5,11b-hexahydro-1H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
• CAS: 34200-35-6
• 化学式: C₁₄H₁₅NO₆
• 分子量: 293.276
• InChiKey: KKAHUDOWKGIGAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  108
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Use of an extract of Lycoris chejuenis and/or a compound isolated therefrom for preventing and/or treating a neurodegenerative disease
  申请人：Korea Institute of Science and Technology

  公开号：EP2226077A1

  公开（公告）日：2010-09-08

  Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a β-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis, and/or dihydrolycoricidinc, 2-methoxypancracinc, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting β-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.

  提供了一种新的用途，即利用枸杞提取物或从中分离出的化合物来抑制β-淀粉样蛋白的产生和/或预防、改善和/或治疗神经退行性疾病，更具体地说是一种β-淀粉样蛋白产生抑制剂、和/或一种用于预防或治疗神经退行性疾病的组合物，该组合物含有一种或多种选自由枸杞提取物、和/或二氢枸杞醇、2-甲氧基潘枸杞醇、枸杞苷和/或枸杞醇组成的组的活性成分；一种抑制β-淀粉样蛋白生成的方法，和/或使用该方法预防和/或治疗神经退行性疾病；以及一种制备该方法的方法。
• Extract of Lycoris chejuenis and/or a compound isolated therefrom for preventing and/or treating a neurodegenerative disease
  申请人：Korea Institute of Science and Technology

  公开号：EP2226077B1

  公开（公告）日：2017-05-03
• Method of preventing and/or treating a neurodegenerative disease by administering an extract of Lycoris chejuensis and/or a compound isolated therefrom
  申请人：Yang Hyun-Ok

  公开号：US20100227851A1

  公开（公告）日：2010-09-09

  Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a neurodegenerative disease, more specifically a β-amyloid production inhibitor, and/or a composition for prevention or treatment of a neurodegenerative disease containing one or more kinds selected from the group consisting of an extract of Lycoris chejuensis , and/or dihydrolycoricidine, 2 -methoxypancracine, lycoricidine, and/or lycoricidinol, as an active ingredient; a method for inhibiting β-amyloid production, and/or preventing and/or treating a neurodegenerative disease using the same; and, a method for preparing the same.
• US9044501B2
  申请人：——

  公开号：US9044501B2

  公开（公告）日：2015-06-02