[3,4,5-Trihydroxy-6-(4-hydroxyphenoxy)oxan-2-yl]methyl 3,4,5-trihydroxybenzoate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [3,4,5-Trihydroxy-6-(4-hydroxyphenoxy)oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
• 英文别名: [3,4,5-trihydroxy-6-(4-hydroxyphenoxy)oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
• 化学式: C₁₉H₂₀O₁₁
• 分子量: 424.4
• InChiKey: KPFBMNKCSZQESS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• CDK5 Inhibitors and Therapeutic Uses Thereof
  申请人：IP Nancy Yuk-Yu

  公开号：US20120270821A1

  公开（公告）日：2012-10-25

  Natural occurring inhibitors of cyclin-dependent protein kinase 5 (Cdk5), isolated from the root of Rhodiola rosea are structurally different from the known Cdk inhibitors. They show selectivity among different Cdks and efficacy to inhibit Cdk via a mixed-type of inhibition, which should lead to less toxicity and side-effects. They are useful in preventing and treating diseases and disorders associated with aberrant Cdk5 activities, such as acute and/or chronic pain, neuropathic pain, diabetes mellitus, cancer, neurodegenerative diseases and neuropathological disorders.
• US9629863B2
  申请人：——

  公开号：US9629863B2

  公开（公告）日：2017-04-25
• [EN] RHODIOLA ROSEA EXTRACTS AND ISOLATED COMPOUNDS AND USES THEREOF FOR TREATING NEURODEGENERATIVE DISEASES<br/>[FR] EXTRAITS ET COMPOSÉS ISOLÉS D'ORPIN ROSE ET LEURS UTILISATIONS POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：UNIV HONG KONG SCIENCE & TECHN

  公开号：WO2013020368A1

  公开（公告）日：2013-02-14

  This invention relates to extract, fractions and isolated compound of Rhodiola rosea, and uses thereof for treating neuropathological and neurodegenerative diseases. The extracts and compounds of the present invention inhibit the aggregation of alpha-synuclein. In one embodiment, Rhodiola rosea extracts and compounds of the present invention can be used to treat synucleinopathies including PD, dementia with Lewy bodies, pure autonomic failure, multiple system atrophy, and Alzheimer's disease.