3,6-Dideoxy-D-ribo-hexose | 147129-67-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6-Dideoxy-D-ribo-hexose
• 英文别名: beta-Tyvelose；6-methyloxane-2,3,5-triol
• CAS: 147129-67-7
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: KYPWIZMAJMNPMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR PRODUCTION OF ASCARYLOSE AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION D'ASCARYLOSE ET DE COMPOSÉS APPARENTÉS
  申请人：ASCRIBE BIOSCIENCE

  公开号：WO2022024067A1

  公开（公告）日：2022-02-03

  This application relates to efficient methods for the synthesis of ascarylose and its derivatives. A method for the production of ascarylose includes: providing, as a feedstock, a 1-O-substituted rhamnose; forming a mono-sulfonate ester at the 3-OH group of the 1-O-substituted rhamnose; and treating the mono-sulfonate ester with a hydride source to form a 1-O-substituted ascarylose. Forming the mono-sulfonate ester can advantageously be conducted on a 1-O-substituted rhamnose without hydroxyl protecting groups at either the 2-OH or 4-OH-positions.

  本申请涉及制备ascarylose及其衍生物的高效方法。一种制备ascarylose的方法包括：提供1-O-取代的鼠李糖作为原料；在1-O-取代的鼠李糖的3-OH基团上形成单磺酸酯；并使用氢化物来源处理单磺酸酯以形成1-O-取代的ascarylose。优选地，在2-OH或4-OH位置均不具有羟基保护基团的1-O-取代鼠李糖上可以有利地形成单磺酸酯。
• Modified strain of Salmonella enterica Typhi
  申请人：PROKARIUM LIMITED

  公开号：US10806778B2

  公开（公告）日：2020-10-20

  The present invention relates to the modification of a live attenuated strain of Salmonella enterica serovar Typhi, wherein its natural surface-exposed polysaccharide and flagellin antigens may be converted to, or augmented by, those from other strains of Salmonella, including S. enterica serovars Paratyphi, Typhimurium and Enteritidis. The present invention also relates to modified strains of Salmonella enterica serovar Typhi being suitable for use as components of a vaccine for enteric fever and salmonellosis.

  本发明涉及对伤寒沙门氏菌减毒活疫苗菌株的改造，其中其天然表面暴露的多糖和鞭毛蛋白抗原可转化为或增加来自其他沙门氏菌菌株的抗原，包括副伤寒沙门氏菌、伤寒沙门氏菌和肠炎沙门氏菌。本发明还涉及适合用作肠炎和沙门氏菌病疫苗成分的肠炎血清伤寒沙门氏菌改良菌株。
• MODIFIED STRAIN OF SALMONELLA ENTERICA TYPHI
  申请人：Prokarium Limited

  公开号：EP3917565A1

  公开（公告）日：2021-12-08
• [EN] MODIFIED STRAIN OF SALMONELLA ENTERICA TYPHI<br/>[FR] SOUCHE MODIFIÉE DE SALMONELLA ENTERICA TYPHI
  申请人：PROKARIUM LTD

  公开号：WO2020157203A1

  公开（公告）日：2020-08-06

  The present invention relates to the modification of a live attenuated strain of Salmonella enterica serovar Typhi, wherein its natural surface-exposed polysaccharide and flagellin antigens may be converted to, or augmented by, those from other strains of Salmonella, including S. enterica serovars Paratyphi, Typhimurium and Enteritidis. The present invention also relates to modified strains of Salmonella enterica serovar Typhi being suitable for use as components of a vaccine for enteric fever and salmonellosis.