2-Methyl-4-(methylamino)-6-methylsulfanylhexan-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-4-(methylamino)-6-methylsulfanylhexan-3-one
• 英文别名: 2-methyl-4-(methylamino)-6-methylsulfanylhexan-3-one
• 化学式: C₉H₁₉NOS
• 分子量: 189.32
• InChiKey: KZJXUFFIDZUEIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds useful in the treatment and/or care of the skin, hair, nails, and/or mucous membranes
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US10799442B2

  公开（公告）日：2020-10-13

  Compounds of general formula (I): R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and/or care of the skin, hair and/or mucous membranes, in particular in the aging and photoaging of the skin.

  通式 (I) 的化合物：R1-Wm-Xn-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2（I）的立体异构体、它们的混合物和/或它们的化妆品或药剂上可接受的盐、含有它们的化妆品和/或药剂组合物，以及它们在医学、皮肤、头发和/或粘膜的治疗和/或护理过程中的用途，尤其是在皮肤老化和光老化方面的用途。
• [EN] CYCLIC PEPTIDYL INHIBITORS OF CAL-PDZ BINDING DOMAIN<br/>[FR] INHIBITEURS PEPTIDYLIQUES CYCLIQUES DU DOMAINE DE LIAISON CAL-PDZ
  申请人：OHIO STATE INNOVATION FOUNDATION

  公开号：WO2019148195A2

  公开（公告）日：2019-08-01

  Described herein, in various embodiments, are peptides comprising: (i) a cyclic cell-penetrating peptide sequence (cCPP) and (ii) a CAL-PDZ binding sequence, which is conjugated, directly or indirectly, to an N-terminus of an amino acid in the cCPP, to a C-terminus of an amino acid on the cCPP, or on a side chain of an amino acid in the cCPP. In other embodiments, the peptides further comprise a physiologically cleavable group, wherein after entering the cell, the physiologically cleavable group is reduced, thereby providing a linear peptide. Without being bound by theory, the inventors discovered that the amino acid sequence in the cCPP, which facilities cytosolic delivery of the CAL-PDZ binding sequence also, surprisingly and unexpectedly, synergistically improves binding of CAL-PDZ binding sequence to the CAL-PDZ binding domain. Additionally, the cCPP sequence may also improve selectivity of the CAL-PDZ binding sequence for the CAL-PDZ domain relative to other PDZ binding domains.