6-o-Phosphonohexopyranosyl hexopyranoside | 10196-10-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-o-Phosphonohexopyranosyl hexopyranoside
• 英文别名: [3,4,5-trihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl dihydrogen phosphate
• CAS: 10196-10-8；4484-88-2
• 化学式: C₁₂H₂₃O₁₄P
• 分子量: 422.28
• InChiKey: LABSPYBHMPDTEL-UHFFFAOYSA-N

物化性质

• 沸点：
  789.7±70.0 °C(Predicted)
• 密度：
  1.89±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  236
• 氢给体数：
  9
• 氢受体数：
  14

文献信息

• Therapeutic approaches for treating CMT and related disorders
  申请人：PHARNEXT

  公开号：US10322101B2

  公开（公告）日：2019-06-18

  Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this disease by decreasing PMP22 expression in a subject.

  治疗夏科-玛丽-牙病及相关疾病的组合物和方法。此外，还提供了通过降低受试者体内 PMP22 表达来治疗该疾病的组合疗法。
• NEW THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS
  申请人：Pharnext

  公开号：EP2211846A1

  公开（公告）日：2010-08-04
• New therapeutic approaches for treating CMT and related disorders
  申请人：Pharnext

  公开号：EP2211846B1

  公开（公告）日：2013-02-27
• THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS
  申请人：Cohen Daniel

  公开号：US20100310641A1

  公开（公告）日：2010-12-09

  The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject.
• US8992891B2
  申请人：——

  公开号：US8992891B2

  公开（公告）日：2015-03-31