7-(4-Hydroxy-3-methoxyphenyl)furo[3,2-g]chromen-5-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-(4-Hydroxy-3-methoxyphenyl)furo[3,2-g]chromen-5-one
• 化学式: C₁₈H₁₂O₅
• 分子量: 308.29
• InChiKey: LDTRZMLTZTZIAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(6-羟基-1-苯并呋喃-5-基)乙酮 在 氢氧化钾 、 碘 作用下， 以 乙醇 、 三乙二醇 为溶剂， 反应 2.0h， 生成 7-(4-Hydroxy-3-methoxyphenyl)furo[3,2-g]chromen-5-one
  参考文献：
  名称：

  Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.

  摘要：

  Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4",5",6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I-2 in trigol is also reported. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.06.048

文献信息

• Isolation and synthesis of analgesic and anti-inflammatory compounds from Ochna squarrosa L.
  作者：V. Anuradha、Pullela V. Srinivas、R. Ranga Rao、K. Manjulatha、Muralidhar G. Purohit、J. Madhusudana Rao

  DOI：10.1016/j.bmc.2006.06.048

  日期：2006.10

  Two new furanoflavonoids (1, 2), one new chalcone dimer (3) along with six known compounds, chrysophanol, 5-O-methyl squarrosin, 5-methoxy furano[4",5",6,7]flavone, calodenone, lophirone A and lophirone H were isolated from the ethyl acetate-soluble fraction of methanol extract of root bark of Ochna squarrosa. Chrysophanol, calodenone, lophirone A and lophirone H were isolated from this plant for the first time. The structures of all the isolated compounds were confirmed by 1D and 2D spectroscopic data. These compounds were tested for analgesic and anti-inflammatory activity. All the new compounds showed good analgesic and anti-inflammatory activity. A simple and facile method for the cleavage of benzyl ethers using I-2 in trigol is also reported. (c) 2006 Elsevier Ltd. All rights reserved.