4,4'-bis(9-phenanthrenylmethylideneamino)diphenyl ether | 1575468-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 4,4'-bis(9-phenanthrenylmethylideneamino)diphenyl ether
• 英文别名: 1-phenanthren-9-yl-N-[4-[4-(phenanthren-9-ylmethylideneamino)phenoxy]phenyl]methanimine
• CAS: 1575468-09-5
• 化学式: C₄₂H₂₈N₂O
• 分子量: 576.697
• InChiKey: LBDNTNPTKMXKNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  45
• 可旋转键数：
  6
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4'-二氨基二苯醚 、 9-甲醛菲 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以91%的产率得到4,4'-bis(9-phenanthrenylmethylideneamino)diphenyl ether
  参考文献：
  名称：

  4,4′-Diaminodiphenyl ether derivatives: Synthesis, spectral, optical, thermal characterization and in-vitro cytotoxicity against Hep 3B and IMR 32 human cell lines

  摘要：

  4,4 '-Diaminodiphenyl ether was selected as a lead compound to prepare a novel series of bisimine derivatives bearing polyaromatic hydrocarbon substituents and their reduced benzyl forms. The new compounds were structurally characterized by microanalysis, mass, IR, H-1, C-13, DEPT-135, HSQC, g-COSY NMR spectroscopy, UV-visible, fluorescence spectrophotometers and by thermogravimetric analysis. The antitumor activity of these derivatives was evaluated in-vitro against Hep 3B and IMR 32 by the MTT assay and the results were compared with cisplatin. Interestingly, some compounds were found extremely active against both the cell lines and proved to be more potent as cytotoxic agents than cisplatin. Morphological evidences suggest the induction of apoptosis and explain the mode of action of these derivatives as antitumor agents. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.035