a-L-threo-4-Hex-4-enopyranuronosyl-D-galacturonic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: a-L-threo-4-Hex-4-enopyranuronosyl-D-galacturonic acid
• 英文别名: 2-(2-carboxy-4,5,6-trihydroxyoxan-3-yl)oxy-3,4-dihydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid
• 化学式: C₁₂H₁₆O₁₂
• 分子量: 352.25
• InChiKey: LLVVMXFNKAHVEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  203
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• Cell-Mediated Directed Evolution
  申请人：Cornish Virginia W.

  公开号：US20090209038A1

  公开（公告）日：2009-08-20

  The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most ‘fit’ mutants.