fenamidone | 151022-37-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: fenamidone
• 英文别名: 4-methyl-4-phenyl-1-(phenylamino)-2-methylthioimidazo-lydin-5-one；4-methyl-1-phenylamino-2-methylthio-4-phenyl-2-imidazolin-5-one；(S)-1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one；3-anilino-5-methyl-2-methylsulfanyl-5-phenylimidazol-4-one
• CAS: 151022-37-6
• 化学式: C₁₇H₁₇N₃OS
• 分子量: 311.407
• InChiKey: LMVPQMGRYSRMIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  fenamidone 、 碘甲烷 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以70%的产率得到4-methyl-1-(N-methyl-N-phenylamino)-2-methylthio-4-phenyl-2-imidazolin-5-one
  参考文献：
  名称：

  Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones

  摘要：

  杀真菌剂2-咪唑啉-5-酮和2-咪唑啉-5-硫酮，它们的制备方法，含有它们的杀真菌组合物，以及使用它们来治疗或预防作物真菌病的方法。

  公开号：

  US06344564B1
• 作为产物：
  描述：

  methyl 2-isothiocyanato-2-phenylpropionate 、 苯肼 、 碘甲烷 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 2.17h， 以77%的产率得到fenamidone
  参考文献：
  名称：

  Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones

  摘要：

  杀真菌剂2-咪唑啉-5-酮和2-咪唑啉-5-硫酮，它们的制备方法，含有它们的杀真菌组合物，以及使用它们来治疗或预防作物真菌病的方法。

  公开号：

  US06344564B1

文献信息

• INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES
  申请人：Melander Christian

  公开号：US20090143230A1

  公开（公告）日：2009-06-04

  Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.

  本公开提供了一种防止、去除或抑制植物或其部分中微生物生物膜形成或微生物感染的方法，包括向其施加本文所述的活性化合物的有效量或其农业可接受的盐。还提供了增强微生物杀灭剂（例如，包括铜、抗生素、噬菌体等）和/或植物防御激活剂的方法，包括施加本文所述的活性化合物。还提供了包含本文所述的活性化合物在农业可接受载体中的组合物，并在某些实施例中，这些组合物进一步包括微生物杀灭剂（例如，包括铜、抗生素、噬菌体等）和/或植物防御激活剂。
• MODULATORS OF ACETYL-COENZYME A CARBOXYLASE AND METHODS OF USE THEREOF
  申请人：Anderson Richard

  公开号：US20080200461A1

  公开（公告）日：2008-08-21

  The present invention provides compounds of formula I: along with methods of use thereof for the control of agricultural pests, particularly fungal pests, weedy pests and insect pests, as well as use as pharmaceuticals, particularly the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease and insulin resistance, e.g., type II or adult-onset diabetes as well as fungal pathogens of humans and animals

  本发明提供了公式I的化合物： 以及使用它们控制农业害虫的方法，尤其是真菌害虫、杂草害虫和昆虫害虫，以及用作药物，特别是治疗肥胖、代谢综合征、动脉硬化、心血管疾病和胰岛素抵抗的方法，例如II型或成年发病型糖尿病以及人类和动物的真菌病原体。
• USE OF ARYL CARBAMATES IN AGRICULTURE AND OTHER PLANT-RELATED AREAS
  申请人：North Carolina State University

  公开号：US20130172187A1

  公开（公告）日：2013-07-04

  Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator.

  本公开提供了一种防止、去除或抑制植物或其部分中微生物生物膜形成或微生物感染的方法，包括向其施加本文所述的芳基氨基甲酸酯或其农业可接受的盐的治疗有效量。还提供了增强微生物杀灭剂（例如，包括铜、抗生素、噬菌体等）和/或植物防御激活剂的方法，包括施加本文所述的活性化合物。还提供了包含本文所述的芳基氨基甲酸酯化合物的组合物，其在农业上可接受的载体中，并且在某些实施例中，这些组合物进一步包括微生物杀灭剂（例如，包括铜、抗生素、噬菌体等）和/或植物防御激活剂。
• Modulators of Acetyl-Coenzyme A Carboxylase and Methods of Use Thereof
  申请人：Anderson Richard

  公开号：US20100009982A1

  公开（公告）日：2010-01-14

  The present invention provides compounds of formula I: along with methods of use of these compounds as pharmaceuticals, particularly in the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, insulin resistance, diseases associated with reduced neuronal metabolism, and cancer as well as the use of these compounds for treatment of pathogens of humans and animals, and for the control of agricultural pests, particularly fungi, weeds and insects.

  本发明提供了I式化合物，以及这些化合物作为药物的使用方法，特别是在肥胖、代谢综合征、动脉粥样硬化、心血管疾病、胰岛素抵抗、与减少神经代谢有关的疾病和癌症的治疗中的应用，以及这些化合物用于治疗人类和动物的病原体，并用于控制农业害虫，特别是真菌、杂草和昆虫。
• 3-Aryl-3-hydroxy-and 3-aryl-3-oxopropionic acid esters as fungicides
  申请人：Lee Shy-Fuh

  公开号：US20050277663A1

  公开（公告）日：2005-12-15

  Compounds of formula I: wherein Ar is aryl, Ar 1 is a 5 or 6-membered aromatic or heteroaromatic group, Z 1 is —OH and Z 2 is H; or Z 1 and Z 2 together are ═O; are described, along with methods of making the same, compositions containing the same, and methods of using the same, particularly as fungicides.

  公式I的化合物：其中Ar是芳基，Ar1是5或6成员芳香或杂芳基团，Z1是—OH，Z2是H；或Z1和Z2一起是 ═O；还描述了制备这些化合物的方法，含有这些化合物的组合物，以及使用这些化合物的方法，特别是作为杀真菌剂。