5,6,7,8-四氢喹噁啉-2-醇 | 27579-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5,6,7,8-四氢喹噁啉-2-醇
• 中文别名: 5,6,7,8-四氢-2-羟基喹喔啉；5，6，7，8-四氢-2-羟基喹喔啉
• 英文名称: 5,6,7,8-tetrahydro-2(1H)-quinoxalinone
• 英文别名: 5,6,7,8-tetrahydroquinoxalin-2(1H)-one；5,6,7,8-tetrahydroquinoxalin-2-one；5,6,7,8-tetrahydro-1H-quinoxalin-2-one；5,6,7,8-Tetrahydro-chinoxalon-(2)；5,6,7,8-Tetrahydroquinoxalin-2-ol；5,6,7,8-tetrahydro-1H-quinoxalin-2-one
• CAS: 27579-58-4
• 化学式: C₈H₁₀N₂O
• 分子量: 150.18
• InChiKey: LSGFRZKZEUUPIP-UHFFFAOYSA-N

物化性质

• 密度：
  1.35±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5,6,7,8-四氢喹噁啉-2-醇 在 三氯氧磷 作用下， 反应 3.0h， 以86%的产率得到2-氯-5,6,7,8-四氢喹喔啉
  参考文献：
  名称：

  RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS

  摘要：

  公开号：

  EP1196410B1
• 作为产物：
  描述：

  1,2-环己二酮 在 三乙胺 作用下， 以 乙醇 、 水 、 二甲基亚砜 、 苯 为溶剂， 反应 25.5h， 生成 5,6,7,8-四氢喹噁啉-2-醇
  参考文献：
  名称：

  N-Hydroxyamide-containing Heterocycles. Part 7. Preparation and Photochemical Behavior of 1-Benzyloxy-2(1H)-pyrazinones

  摘要：

  DOI：

  10.3987/com-96-7392

文献信息

• Photochemical Reactions of Tetrahydroquinoxalin-2(1H)-ones and Related Compound
  作者：Takehiko Nishio、Masaji Kondo、Yoshimori Omote

  DOI：10.1002/hlca.19910740122

  日期：1991.1.30

  Photochemical behaviors of the pyrazinone derivatives 5,6,7,8-tetrahydroquinoxalin-2(1H)-ones 1a–c and 1,5,6,7,8,9-hexahydro-2H-cyclohepta[b]pyrazin-2-one 1d were investigated. Dye-sensitized photo-oxygenation of 1a-c gave the 1:1 adducts 5a–c of the corresponding 3,8a-epidioxy-3,5,6,7,8,8a-hexahydroquinoxalin-2(1H)-one 4 and H2O, whereas 1d gave 3,9a-epidioxy-1,3,5,6,7,8,9,9a-octahydro-2H-cyclohepta[b]pyrazin-2-one

  吡嗪酮衍生物5,6,7,8-四氢喹喔啉-2（1 H）-ones 1a – c和1,5,6,7,8,9-hexahydro-2 H -cyclohepta [ b ]吡嗪-的光化学行为研究了2个1d模型。染料敏化的1a-c光氧合得到相应的3,8a-epidioxy-3,5,6,7,8,8,8a-六氢喹喔啉-2（1 H）-one 4的1：1加合物5a – c和H 2 O，而1d得到3,9a-epidioxy-1,3,5,6,7,8,9,9a-octahydro-2 H -cyclohepta [ b ]吡嗪-2-one 4d（方案2）。不同种类的产物被解释为由单线态氧与1a - d生成的内过氧化物的环应变和空间位阻的结果。在烯烃存在下辐照1a – b可通过[2 + 2]将1的CN键与烯烃环加成而得到三环氮杂环丁烷衍生物9。
• [EN] INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS<br/>[FR] INDAZOLES ET AZAINDAZOLES EN TANT QU'INHIBITEURS DE LRRK2
  申请人：ESCAPE BIO INC

  公开号：WO2021178780A1

  公开（公告）日：2021-09-10

  The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

  本发明涉及一种抑制LRRK2的吲唑和杂氮吲唑化合物，可用于治疗中枢神经系统疾病。
• NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE
  申请人：Shibayama Kotaro

  公开号：US20140073792A1

  公开（公告）日：2014-03-13

  An agricultural or horticultural fungicide contains as an active ingredient thereof at least one compound selected from the group consisting of nitrogenated heterocyclic compounds represented by formula (I) (wherein, R represents a group represented by CR 1 R 2 R 3 or a cyano group, R 1 to R 3 represent hydrogen atoms, alkyl groups or hydroxyl groups, or the like, X 1 represents a halogeno group or the like, m represents an integer of 0 to 5, X 2 represents a halogeno group or the like, n represents an integer of 0 to 3, B represents a carbon atom or a nitrogen atom, D represents a 5- to 7-membered hydrocarbon ring, and A 1 to A 4 represent carbon atoms or nitrogen atoms, provided that A 1 to A 4 do not all represent carbon atoms when B represents a carbon atom) and salts thereof.

  一种农业或园艺用的杀菌剂，其活性成分至少包含以下化合物之一，所述化合物选自由式(I)所代表的含氮杂环化合物组成的群体（其中，R代表由CR1R2R3或氰基表示的基团，R1至R3代表氢原子、烷基或羟基等，X1代表卤素基团等，m表示0至5的整数，X2代表卤素基团等，n表示0至3的整数，B代表碳原子或氮原子，D代表5至7成员的碳氢环，A1至A4代表碳原子或氮原子，但当B代表碳原子时，A1至A4不全为碳原子）及其盐。
• 2-alkoxy-5,6,7,8-tetrahydroquinoxaline derivatives, and production
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US05578596A1

  公开（公告）日：1996-11-26

  Disclosed are a compound represented by formula (1) and a non-toxic salt thereof, a production method thereof, and a pharmaceutical composition for treating a serotonergic neuron-related disease comprising the same as an active ingredient: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a pyridyl group which is unsubstituted or substituted with 1 to 3 substituents each independently selected from the group consisting of a halogen atom, a lower alkyl group, a trifluoromethyl group, a lower alkoxy group, a carbamoyl group and a cyano group, or a pyrimidinyl group which is unsubstituted or substituted with 1 to 2 substituents each independently selected from the group consisting of a lower alkyl group and a lower alkoxy group; and n is an integer of from 2 to 5. Compound (1) of the present invention and a non-toxic salt thereof have a strong affinity for serotonin 1A receptor and, therefore, they are useful for preventing and treating serotonergic neuron-related diseases, such as motion sickness, space sickness, emesis, dizziness, depression, anxiety, eating disorder, and the like.

  本发明公开了一种由式（1）表示的化合物及其无毒盐，其制备方法，以及包含其作为活性成分的用于治疗与5-羟色胺神经元相关疾病的药物组合物：##STR1##其中R.sup.1代表氢原子或较低的烷基基团；R.sup.2代表未取代或取代有1至3个取代基的吡啶基，每个取代基独立地选自卤原子、较低的烷基基团、三氟甲基基团、较低的烷氧基团、氨基甲酰基团和氰基等团组成的群，或未取代或取代有1至2个取代基的嘧啶基，每个取代基独立地选自较低的烷基基团和较低的烷氧基团；n为2至5的整数。本发明的化合物（1）及其无毒盐对5-羟色胺1A受体具有很强的亲和力，因此它们对预防和治疗与5-羟色胺神经元相关的疾病，如晕动病、太空病、呕吐、头晕、抑郁、焦虑、进食障碍等非常有用。
• Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA
  申请人：Neurogen Corporation

  公开号：US05306819A1

  公开（公告）日：1994-04-26

  The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## where W represents an aromatic group substituted with various organic and inorganic substituents; X, Y are hydrogen, halogen, hydroxy or amino with the proviso that at least X or Y is hydroxy; A, B C, and D, represent nitrogen or a carbon atom substituted with various organic and inorganic substituents; E represents oxygen, sulfur or substituted nitrogen; R.sub.3, R.sub.4, R.sub.12, and R.sub.13 are variables representing various organic and inorganic substituents; and n is 0, 1, or 2.

  本发明涵盖以下结构：##STR1##及其药学上可接受的无毒盐，其中： ##STR2## 其中W代表带有各种有机和无机取代基的芳香基; X、Y代表氢、卤素、羟基或氨基，但至少X或Y是羟基; A、B、C和D代表氮或带有各种有机和无机取代基的碳原子; E代表氧、硫或取代的氮; R.sub.3、R.sub.4、R.sub.12和R.sub.13是表示各种有机和无机取代基的变量; n为0、1或2。