4-Cinnamylidene-2-hydroxy-5-methoxycyclohexa-2,5-dien-1-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Cinnamylidene-2-hydroxy-5-methoxycyclohexa-2,5-dien-1-one
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.28
• InChiKey: LUZUAYAKZLCOCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] METHODS AND MATERIALS FOR MODULATING NRF2 PATHWAY<br/>[FR] MÉTHODES ET SUBSTANCES DE MODULATION DE LA VOIE NRF2
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2021067799A1

  公开（公告）日：2021-04-08

  The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.

  本申请提供了调节Nrf2通路的方法和化合物。同时还提供了治疗癌症和神经退行性疾病的方法。
• Identification of Small Molecule Inhibitors of Jumonji AT-Rich Interactive Domain 1A (JARID1A) and 1B (JARID1B) Histone Demethylase
  申请人：Yale University

  公开号：US20150272939A1

  公开（公告）日：2015-10-01

  The present invention includes a novel high-throughput screen capable of identifying compounds that inhibit JARID1B demethylase activity or JARID1A demethylase activity. The present invention further includes novel inhibitors of JARID1B demethylase activity and/or JARID1A demethylase activity, and methods using the same.
• METHODS AND MATERIALS FOR MODULATING NRF2 PATHWAY
  申请人：The General Hospital Corporation

  公开号：US20220395577A1

  公开（公告）日：2022-12-15

  The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.
• US4012529A
  申请人：——

  公开号：US4012529A

  公开（公告）日：1977-03-15