1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-pyridine-3-carboxamide
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.25
• InChiKey: MAKBMGXNXXXBFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
  申请人：Cornell University

  公开号：US10392414B2

  公开（公告）日：2019-08-27

  Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.

  本发明公开了一种式 (I) 的化合物： 其中 R1、R2、R3 和如本文所定义。还公开了提高哺乳动物细胞 NAD+ 产量和改善线粒体细胞密度的方法，包括向细胞施用化合物或其盐。
• Methods for improving cognitive function via modulation of quinone reductase 2
  申请人：Carmel-Haifa University Economic Corp. Ltd.

  公开号：US10676747B2

  公开（公告）日：2020-06-09

  An active agent capable of reducing quinone reductase 2 activity is for use in improvement of cognition in a subject. Such an active agent can be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A pharmaceutical composition can contain the active agent or a vector containing the active agent.

  一种能够降低醌还原酶 2 活性的活性剂可用于改善受试者的认知能力。这种活性剂可以是降低醌还原酶 2 基因表达水平的核酸分子，也可以是醌还原酶 2 活性的抑制剂。药物组合物可以含有活性剂或含有活性剂的载体。
• SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES
  申请人：Cornell University

  公开号：US20180208619A1

  公开（公告）日：2018-07-26

  Disclosed is a compound of formula (I): wherein R 1 , R 2 , R 3 , and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD + production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
• METHODS FOR IMPROVING COGNITIVE FUNCTION VIA MODULATION OF QUINONE REDUCTASE 2
  申请人：Carmel-Haifa University Economic Corp. Ltd.

  公开号：US20190119684A1

  公开（公告）日：2019-04-25

  An active agent capable of reducing quinone reductase 2 activity is for use in improvement of cognition in a subject. Such an active agent can be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A pharmaceutical composition can contain the active agent or a vector containing the active agent.
• [EN] METHODS FOR IMPROVING COGNITIVE FUNCTION VIA MODULATION OF QUINONE REDUCTASE 2<br/>[FR] PROCÉDÉS POUR AMÉLIORER LA FONCTION COGNITIVE PAR L'INTERMÉDIAIRE DE LA MODULATION DE L'ACTIVITÉ DE LA QUINONE RÉDUCTASE 2
  申请人：UNIV CARMEL HAIFA ECONOMIC COR

  公开号：WO2015140799A1

  公开（公告）日：2015-09-24

  An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.